IMAGES IN NEUROPATHOLOGY MINICOURSE PRESENTED BY WILLIAM I ROSENBLUM MD

CELL IDENTIFICATION IN NEUROPATHOLOGY

ASTROCYTES WITH FOOT PROCESSES [CAJAL STAINED]

ASTROCYTES GOLD [CAJAL] STAINED

ASTROCYTES-REACTIVE H&E

ASTROCYTES - PTAH STAINED-PROCESSES PURPLE

OLIGODENDROGLIA-H&E STAINS ONLY THEIR NUCLEI

MICROGLIA AS ROD CELLS -SILVER STAINED

NEURON -H&E

SOME BASIC NEUROHISTOLOGY AND HISTOPATHOLOGY

MICROGLIA IN TERTIARY SYPHILIS--SILVER STAINED

NEURON-NISSL STAINED-CENTRAL CHROMATOLYSIS

NEURON-NEURONOPHAGIA

NEURON-NEGRI BODY [RABIES]

NEURON-NEUROMELANIN IN NEURONS SUBST NIGRA

NEURON-LEWY BODY [PARKINSONS OR DIFFUSE LEWY BODY DEMENTIA]

NEURON-INTRANUCLEAR INCLUSION BODY [E.G. HERPES SIMPLEX]

NEURON-STORAGE DISEASE

NEUROFIBRILLARY TANGLE-ALZHEIMER'S DISEASE

WALLERIAN DEGENERATION IN CORTICO-SPINAL TRACTS

IMAGES RELATED TO INFARCTION

RED [EOSINOPHILIC]  NEURONS INDICATIVE OF ACUTE ISCHEMIA

MACROPHAGES-PEAK ABOUT 10 DAYS AFTER INFARCT THEN LARGELY DISAPPEAR OVER TIME

REACTIVE ASTROCYTES -PEAK ABOUT 2-3 WEEKS AFTER INFARCT THEN CAN REMAIN IN LARGE NUMBER

REACTIVE ASTROCYTES AT MARGIN OF OLD INFARCT-STAINED WITH PTAH

 OLD INFARCTS ARE CYSTIC-GROSS PHOTO

IMAGES RELATED TO HEMORRHAGE

GROSS HEMORRHAGE IS A MASS OF BLOOD DISSECTING INTO TISSUE

GROSS  HEMORRHAGE VERSUS HEMORRHAGIC INFARCT: MASS OF BLOOD [FRESH HEMORRHAGE]  FELL OUT OF BRAIN SHOWING SPACE IT MADE FOR ITSELF IN LEFT HEMISPHERE. GYRUS ABOVE IT SHOWS SOFT, BROWN DISCOLORED TISSUE INDICATIVE OF HEMORRHAGIC INFARCT.

GROSS--OLD HEMORRHAGE--IS JUST A SLIT. CONTRAST WITH IMAGE OF OLD INFARCT

SECONDARY BRAIN STEM HEMORRHAGE CAUSED BY HERNIATION

BERRY ANEURYSMS-GROSS

BERRY ANEURYSM-MICRO TRICHROME-NECK OF ANEURYSM- NORMAL TO LEFT WITH RED SMOOTH MUSCLE; ANEURYSM TO RIGHT LACKS SMOOTH MUSCLE

BERRY ANEURYSM MICRO- ELASTICA STAIN-SHOWS LACK OF ELASTIC LAMELLA AT ANEURYSM

FIBRINOID NECROSIS-H&E-OCCURS IN HYPERTENSION- ARTERIOLES CAN RUPTURE OF FORM MILIARY ANEURYSM WHICH MAY RUPTURE

FIBRINOID NECROSIS IN ANEURYSMAL DILATION-TRICHROME [AZO CARMINE STAIN] STAINS COLLAGEN-EVEN HYALINIZED COLLAGEN-BLUE,  BUT STAINS FIBRINOID [FIBRIN LIKE MATERIAL] RED , OR PINK

FIBRINOID NECROSIS-TRICHROME-RED

FIBRINOID NECROSIS-TRICHROME-SMALL ARTERY IN SUBARACHNOID SPACE SURROUNDED BY NORMAL ARTERIAL SEGMENTS

A HEALED OR FIBROSED MILIARY ANEURYSM-APPEARS AS A FIBROUS GLOBE OR BALL.THIS ONE STAINED WITH ELASTICA STAIN WHICH SHOWS REMNANTS OF ORIGINAL ARTERY AT ITS ROOT

MILIARY ANEURYSM-FIBROSED OR HEALED-SEE PREVIOUS IMAGE

MILIARY ANEURYSM-A HEALED [FIBROSED] ANEURYSM SECTIONED NEAR ITS CONNECTION BY AS NARROW NECK TO THE PARENT ARTERY.

IMAGES RELATED TO DEMENTIAS

ATROPHY

SENILE PLAQUE

AMYLOID

DIFFUSE PLAQUES

NEUROFIBRILLARY TANGLE

HIRANO BODIES

ELECTRON MICROSCOPIC IMAGE OF HYPERPHOSPHORYLATED TAU

LEWY BODIES

IMAGES RELATED TO DISEASES OF MYELIN

ACUTE DISSEMINATED ENCEPHALOMYELITIS

MULTIPLE SCLEROSIS -GROSS

MULTIPLE SCLEROSIS-MICRO

GLOBOID BODIES-KRABBES DISEASE

CANAVANS DISEASE-MICRO

CANAVANS DISEASE-ELECTRON MICROSCOPY

IMAGES OF NEURONAL STORAGE DISEASES

NEURONAL STORAGE DISEASE [e.g.TAY SACHS]-MICRO

NEURONAL STORAGE DISEASE-ELECTRON MICROSCOPY

IMAGES RELATED TO CEREBRAL EDEMA

CEREBRAL EDEMA-GROSS-MARKED BY SPREAD OF BILIVERDIN STAINED PLASMA INTO EDEMATOUS ZONE IN JAUNDICE

CEREBRAL EDEMA EXPANDS WHITE MATTER ADJACENT TO ABSCESS

CEREBRAL EDEMA SPREADS TO ENLARGE WHITE MATTER DISTANT FROM SITE OF ORIGIN

IMAGES OF DEVELOPMENTAL DEFECTS [CONGENITAL DISEASES]

ANENCEPHALLY

ANENCEPHALLY SHOWING NUB OF VASCULAR TISSUE WHERE CEREBRUM SHOULD BE

ENCEPHALOCELE

HYDROCEPHALUS

AQUEDUCTAL STENOSIS -GROSS- A CAUSE OF HYDROCEPHALUS AND FREQUENTLY PRESENT  IN ARNOLD CHIARI

AQUEDUCTAL STENOSIS -MICRO

ARNOLD CHIARI MALFORMATION-GROSS

CHIARI MALFORMATION WITH PEGS OF CEREBELLAR TISSUE BELOW LEVEL OF  FORAMEN MAGNUM

HYDROMYELIA-GROSS

MYELOCELE-ALMOST ALWAYS PRESENT IN ARNOLD CHIARI

AGENESIS CORPUS CALLOSUM

DOWN'S SYNDROME-GROSS- THIN SUPERIOR TEMPORAL GYRUS

IMAGES OF INFECTIONS

MENINGITIS, PURULENT-GROSS

MENINGITIS-MICRO SHOWING POLYS

ABSCESS-GROSS

ABSCESS-MICRO-3 PORTIONS--THE INNER  MASS OF PUSS, THE SURROUNDING GRANULATION TISSUE AND THE OUTER FIBROUS CAPSULE

CRYPTOCOCCAL YEAST FORMS

GRANULOMA WITH GIANT CELLS AS IN FUNGAL, SARCOID OR TB

MILIARY TB GROSS-ARROWS POINT TO GRANULOMATA

TUBERCULOMA-GROSS

TUBERCULAR GRANULOMA-MICRO-CASEUM IN CENTER, FIBROBLASTS AND GIANT CELLS AT PERIPHERY

SYPHILLIS-MICRO-PLASMA CELLS AROUND ARTERY IN MENINGOVASCULAR SYPHILLIS

HEUBNER'S ARTERITIS IN TERTIARY SYPHILLIS-OBLITERATIVE ENDARTERITIS

SYPHILLIS-GENERAL PARESES-ONE FORM OF TERTIARY SYPHILLIS-MANY MICROGLIAL ROD CELLS IN CERERBRUM

SYPHILLIS-TABES DORSALIS-ANOTHER FORM OF TERTIARY SYPHILLIS

TOXOPLASMOSIS GROSS-CALCIFICATION AROUND VENTRICLES

TOXOPLASMOSIS-MICRO- ORGANISMS IN MICROCYST

HERPES SIMPLEX-GROSS-HEMORRHAGIC, MOST OFTEN TEMPORAL LOBES

HERPES SIMPLEX INTRACYTOPLASMIC INCLUSION

CYTOMEGALIC DISEASE--MICRO-ALSO CHARACTERIZED BY CALCIFICATIONS

RICKETSIAL DISEASE-MICRO-VASCULITIS WITH  INFLAM CELLS IN VESSEL WALL AND SURROUNDING AREAS OF MICROGRANULAOMATA CHARACTERIZE AS ALWAYS BY ELONGATE MICROGLIA AND OTHER MONONUCLEAR CELLS.

TUMORS AND OTHER "MASSES"

COLLOID CYST OF THIRD VENTRICLE

ACOUSTIC NEUROMA-GROSS

NERVE SHEATH TUMOR-"SCHWANNOMA" -VEROCAY BODIES PALLISADING IN AN ANTONI "A" ZONE

NEUROFIBROMA-MICRO

MENINGIOMA-GROSS

MENINGIOMA-MICRO

MENINGIOMA-PSAMMOMA BODY

ARACHNOID REST-MICRO- A SOURCE OF MENINGIOMAS

ASTROCYTOMA-CYSTIC- IN CEREBELLUM-GROSS-A PILOID ASTROCYTOMA---A BENIGN TUMOR

ASTROCYTOMA GRADE ONE-MICRO

ASTROCYTOMA GRADE TWO-MICRO

ASTROCYTOMA-MICRO-GRADE 2-3

GLIOBLASTOMA MULTIFORMI [ASTROCYTOMA GRADE 4]-GROSS-HAS CROSSED MIDLINE IN "BUTTERFLY" PATTERN

ASTROCYTOMA-GIANT CELL VARIANT-A GRADE 3-4 TUMOR CONSIDERED SUBTYPE OF GLIOBLASTOMA

ASTROCYTOMA-MICRO-SHOWS SO-CALLED VASCULAR HYPERPLASIA-A "SECONDARY" CHARACTERISTIC OF GRADE 3-4 GLIOMAS

GLIOMA-MICRO-PSEUDOPALISADING AROUND NECROSIS-THE NECROSIS CONSIDERED BY MANY TO BE ESSENTIAL FOR A DIAGNOSIS OF GRADE 4

EPENDYMOMA-MICRO SHOWING ROSETTES

OLIGODENDROGLIOMA-MICRO

MEDULLOBLASTOMA-GROSS

MEDULLOBLASTOMA-MICRO

MEDULLOBLASTOMA METASTASES DOWN SUBARACHNOID SPACE TO REACH NERVE ROOTS ADJACENT TO SPINAL CORD

LYMPHOMA-MICRO

CRANIOPHARYNGIOMA-GROSS

CRANIOPHARYNGIOMA-MICRO-"K" IS KERATINIZED AREA; "E" IS EPITHELIAL AREA

CHORDOMA-MICRO-

METASTATIC TUMOR-GROSS- NOTE IT IS WELL CIRCUMSCRIBED

IMAGES RELATED TO DISEASES OF MUSCLE

MUSCLE-NADH STAIN SHOWING NORMAL CHECKERBOARD OF TYPE ONE AND TYPE TWO FIBERS

MUSCLE-DIAGRAM SHOWING HOW INNERVATION FR0M TYPE ONE OR TWO NERVES DETERMINES MUSCLE FIBER TYPE.

MUSCLE-DIAGRAM SHOWS HOW DENERVATI0N LEADS TO ATROPHY OF FIBERS IN GROUPS WITHIN THE DENERVATED FIELD

MUSCLE-H&E STAIN SHOWING A SMALL ATROPHIC GROUP OF DENERVATED FIBERS

MUSCLE-H&E SHOWING A MORE MASSIVE EXAMPLE OF GROUP ATROPHY DUE TO DENERVATION

MUSCLE-HISTOCHEMICAL STAIN [EITHER ATPase OR NADH - IT DOES NOT MATTER--SHOWING TYPE GROUPING INSTEAD OF CHECKERBOARD IN AN OTHERWISE NORMAL APPEARING MUSCLE.. TYPE GROUPING DUE TO REINNERVATION

MUSCLE-H&E-PHAGOCYTOSIS IN MYOPATHY

MUSCLE-H&E OF REGENERATING FIBER

MUSCLE-DIVERSE FIBER SIZE IN MYOPATHY

MUSCLE-CENTRALLY PLACED NUCLEI IN MYOPATHY

MUSCLE-DIVERSE FIBER SIZE AND CENTRALLY PLACED NUCLEI IN MYOPATHY

MUSCLE-FIBER SPLITTING IN MYOPATHY

MUSCLE-RING FIBER AS IN MYOTONIC DYSTROPHY

MUSCLE-VACUOLATED FIBERS AS IN GLYCOGEN STORAGE

MUSCLE-H&E DYSTROPHY

MUSCLE-ENZYME STAIN IN DYSTROPHY-SHOWS THAT ALL FIBER TYPES WERE AFFECTED.

MUSCLE-SEVERE DYSTROPHY

MUSCLE-INFLAMMATION IN MYOSITIS

MUSCLE-PERIFASCICULAR ATROPHY IN MYOSITIS

MUSCLE-PHOSPHORYLASE STAIN SHOWING ABSENCE OF ENZYME IN BIOPSY FROM GLYCOGEN STORAGE DISEASE IN LOWER LEFT PORTION OF SLIDE. REST IS FROM NORMAL MUSCLE.

MUSCLE-H&E-GLYCOGEN STORAGE-GLYCOGEN WASHED OUT DURING PROCESSING

MUSCLE-GLYCOGEN STORAGE-LEFT PANEL  PHOSPHPORYLASE STAIN -RIGHT PANEL NADH. SHOWS THAT LOSS OF PHOSPHORYLASE IS IN ALL FIBER TYPES

MUSCLE-PTAH STAIN-NEMALINE MYOPATHY WITH "RODS CLUSTERED AT PERIPHERY OF FIBERS

MUSCLE-NEMALINE MYOPATHY-LONGITUDINAL SECTION-ARROWS TO ROD LIKE CLUSTERS

MUSCLE-TRICHROME STAIN-CENTRAL CORE DISEASE

IMAGES RELATED TO TRAUMA

SUBDURAL HEMORRHAGE-FRESH-GROSS

SUBDURAL HEMORRHAGE-ORGANIZED-GROSS [SUBDURAL"MEMBRANES"]

TRAUMA-SUBDURAL HEMORRHAGE-ORGANIZED- WHOLE MOUNT-TRICHROME STAINS COLLAGEN GREEN.

SUBDURAL HEMORRHAGE-ORGANIZING-MICRO

BULLET WOUND TO BRAIN

TRAUMATIC HEMORRHAGES

CONTUSIONS-GROSS

CONTUSION-OLD-MICRO-CYST EXTENDS TO ARACHNOID MEMBRANE

CORD TRANSECTION-GROSS

WALLERIAN DEGENERATION DORSAL COLUMNS [ARROWS] ABOVE TRANSECTION-MYELIN STAIN

WALLERIAN DEGENERATION CORTICOSPINAL TRACTS  BELOW LEVEL OF TRANSECTION-MYELIN STAIN