Acute Pyelonephritis

Click on images for an enlarged version in a separate window (usually 800 x 600 pixels). The digital photomicrographs were acquired either with the Nikon DMX-1200 Digital Photomicroscopy System or an Olympus DP-10 Digital Photomicroscopy Camera.

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Fig. 1. Gross photograph of a kidney with acute pyelonephritis and a large abscess. the renal capsule has been pulled away to reveal the abscess.
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Fig. 2. Panoramic diagram illustrating major pathologic features of acute pyelonephritis (H&E stain, original magnification 200x).
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Fig. 3. Border of abscess showing dense acute inflammatory infiltrate with vascular congestion and tubular degeneration at the margin of an abscess (H&E stain, original magnification 200x).
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Fig. 4. Renal tissue showing the microscopic hallmark of acute pyelonephritis, intratubular aggregations of polymorphonuclear leukocytes (PMNs). The surrounding tissue shows tubular degeneration and interstitial inflammation, with a mixture of image PMNs, lymphocytes, and plasma cells. (H&E stain, original magnification 200x).
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Fig. 5. Acute pyelonephritis with intratubular PMNs ("WBC casts"), intratubular RBCS, interstitial inflammation, and vascular congestion. The glomeruli are rleatively uninvolved by the inflammatory process (H&E stain, original magnification 200x).
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Fig. 6. A higher magnification photomicrograph showing several intratubular RBC casts. Hemosiderin pigment is present in the surrounding interstitial tissue, indicating previosu extravasation of RBCs (H&E stain, original magnification 200x).
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Fig. 7. Intratubular WBCs (H&E stain, original magnification 200x).
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Fig. 8. Close-up of intratubular RBCs and WBCs (H&E stain, original magnification 400x).
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Fig. 9. Interstitial acute inflammation with tubular destruction (H&E stain, original magnification 400x).
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Fig. 10. Intratubular RBCs and interstitial inflammation (H&E stain, original magnification 400x).
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Fig. 11. Congested glomerulus with tubular atrophy and vascular congestion (H&E stain, original magnification 400x).
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Fig. 12. Close-up of degenerating tubule with intraluminal necrotic material (H&E stain, original magnification 400x).
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Fig. 13. Close-up of WBC cast (H&E stain, original magnification 400x).

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