Diabetic Glomerulosclerosis

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Fig. 1. Gross photograph of a kidney with diffuse diabetic glomerulosclerosis. The specimen was from an 81 year-old female with a history of adult-onset diabetis mellitus for 15 years. Note fine granularity of cortical surface.
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Fig. 2. Panoramic image of nodulardiabetic glomerulosclerosis. Note globally sclerotic glomeruli and extensive tubular atrophy. Two non-sclerotic glomeruli show glomerular mesangial increase and nodular intraglomerular masses of hyaline material (Kimmelsteil-Wilson disease) .
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Fig. 3. Panoramic image of nodular diabetic glomerulosclerosis. Note glomerulus showing marked mesangial increase, thickened capillary basement membranes, and multiple nodular masses of hyaline material.
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Fig. 4. Panoramic image of nodular diabetic glomerulosclerosis. Note glomerulus showing marked mesangial increase, thickened capillary basement membranes, and multiple nodular masses of hyaline material.
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Fig. 5. Electron micrograph showing uniform thickening of capillary basement membrane.

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