Focal Segmental Glomerulosclerosis

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Fig. 1. Light micrograph showing a glomerulus with segmental saclerosis and collapsed capillaries (H&E stain, original magnification x400).
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Fig. 2. Light micrograph showing a glomerulus with segmental saclerosis and collapsed capillaries. A small hyaline deposit is present (H&E stain, original magnification x400).
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Fig. 3. Light micrograph of a glomerulus with rather extensive sclerosis involving the majority of the glomerular lobules. Note adhesion of involved lobules to Bowman's capsule (PAS stain, original magnification x400).
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Fig. 4. Light micrograph of a glomerulus with extensive sclerosis. Note adhesion of involved lobules to Bowman's capsule. Surrounding renal tissue shows interstitial fibrosis and tubular atrophy (PAS stain, original magnification x400).
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Fig. 5. Low-power light micrograph showing glomerular sclerosis and effacement of the tubulointerstitium in a case of advanced FSGS (PAS stain, original magnification x100).
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Fig. 6. Low-power light micrograph showing glomerular sclerosis and effacement of the tubulointerstitium in a case of advanced FSGS (PAS stain, original magnification x100).
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Fig. 7. Fluorescence microscopy of renal biopsy stained with FITC-labeled antihuman IgM. Note segmental deposits of IgM with sparing of some portions of the glomerulus.
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Fig. 8. Fluorescence microscopy of renal biopsy showing segmental deposits of C3 complement.
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Fig. 9. Electron micrograph of a sclerotic segment of a glomerulus with FSGS. Note capillary collapse and mesangial sclerosis.
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Fig. 10. Electron micrograph of a sclerotic segment of a glomerulus with FSGS. Note capillary collapse and mesangial sclerosis.
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Fig. 11. Electron micrograph of a sclerotic segment of a glomerulus with FSGS. Note collapse and wrinkling of capillary basement membranes.

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