Membranoproliferative
Glomerulonephritis, Type II

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Fig. 1. Light micrograph showing three glomeruli with a diffuse moderate increase in cellularity, a slight accentuation of mesangial matrix, and slight thickening of peripheral capillary walls. The renal tubules, interstitium, and vessels ane histologically unremarkable (H&E stain, original magnification x100).
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Fig. 2. Light micrograph of four glomeruli showing features described in Fig. 1 (H&E stain, original magnification x100).
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Fig. 3. Glomerulus showing mild hypercellularity, a slight increase in the amount of mesangial matrix, and mild thickening of peripheral capillary walls. The surrounding tissue is unremarkable (H&E stain, original magnification x200).
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Fig. 4. Glomerulus with moderate hypercellularity, slight accentuation of mesangial matrix, and slight thickening of peripheral capillary walls (PAS stain, original magnification x200).
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Fig. 5. Close-up of glomerulus shown in Fig. 4 (PAS stain, original magnification x400).
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Fig. 6. Trichrome stain showing slight mesangial prominance (Masson's trichrome stain, original magnification x200).
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Fig. 7. Fluorescence microscopy of glomerulus stained with FITC-labeled anti-human C3 complement. There are diffuse, finely granular deposits of C3 complement in the mesangium and some capillary basement membranes.
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Fig. 8. Electron micrograph showing characteristic ribbon-like electron-dense deposit formation within the glomerular basement membrane.

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