CNS Pathology for Medical II Students

Lab 1e Slides 25.1-25.3--Medulloblastoma

This is a malignant tumor in children that arises in the cerebellum usually in the vermis. The histology of this tumor is characterized by extreme cellularity and little stroma. The tumor cells are primitive neuroectodermal in nature and may differentiate to both neuronal and glial elements. These tumors grow into the fourth ventricle causing obstructive hydrocephalus and also frequently spread along the CSF pathways.

Slides 25.1 & 25.2 | Slide 25.3

Slide 25.1
The individual tumor cells are small, ovoid or slightly elongated with high nuclear cytoplasmic ratio. Except for an occasional blood vessel, no stroma is seen.

 tumor

Slide 25.2
Gross appearance of a medulloblastoma arising from the cerebellum and growing into the fourth ventricle.

medulloblastoma

Digital Legends for Labs/Cases
Lab 1
1.a | 1.b | 1.c | 1.d | 1.e

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Updated August 28, 2007