CARCINOMA OF THE PROSTATE

• PATHOGENESIS

  • HORMONAL FACTORS
    • DOES NOT OCCUR IN EUNUCHS
    • ORCHIECTOMY AND/OR ESTROGEN TREATMENT INHIBITS GROWTH
  • GENETIC FACTORS
    • INCREASED RISK IN FIRST ORDER RELATIVES
    • BLACKS > WHITES (SYMPTOMATIC CA)
  • ENVIRONMENTAL FACTORS
    • GEOGRAPHIC DIFFERENCES IN INCIDENCE OF CLINICAL CANCER (NOT OF LATENT CA)
    • CHANGE IN INCIDENCE WITH MIGRATION

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