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Electron
Microscopy for Pathologists: Kidney Pathology
A. Amyloidosis
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Image 1
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Amyloidosis includes a variety of conditions involving deposition
of one of a variety of proteins in a Beta-pleated sheet
configuration. At low magnification, the bulk of amyloid fibril
deposits are present in the mesangium with encroachment on
glomerular capillary lumina.
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Image 2 of 2
At higher magnification, the amyloid fibrils are haphazardly
arranged, long non-branching filaments measuring 8-12 nm in width.
When present in the glomerular basement membrane, amyloid fibrils
may display a perpendicular orientation. Ultrastructural
distinction of amyloid from other fibrillary structures in the
kidney is based primarily on size.
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Anti-GBM antibody disease (crescentic
glomerulonephritis)
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