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Electron Microscopy for Pathologists:
Kidney Pathology
F. Focal segmental glomerulosclerosis
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Image
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Focal segmental glomerulosclerosis is associated clinically with
severe proteinuria or the nephrotic syndrome. Hematuria is also
commonly observed by urinalysis. On electron microscopy, foot
process fusion is common.
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Image
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Widespread visceral foot process fusion is identified. Here the
lamina densa is prominent, but no electron dense deposits are
present.
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Image
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Fusion and flattening of the foot processes is present along with
mild microvillous transformation of the foot process. The GBM is
otherwise of normal thickness. No electron dense deposits are
found.
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Image 4 of 4
In this image, at the top is an unaffected portion of glomerulus in
which podocytes are not fused. Below, in the zone of GBM wrinkling
and collapse, focal foot process fusion can be seen.
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Focal segmental glomerulosclerosis suggestive of Fabry's disease
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