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Electron Microscopy for Pathologists: Kidney Pathology
J. Membranoproliferative glomerulonephritis, type I 

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Image 1 of 3
A key ultrastructural feature of membranoproliferative glomerulonephritis is splitting of the glomerular basement membrane by cytoplasmic extensions of phagocytic cells that are attempting to engulf numerous small subendothelial electron dense deposits. Here, mesangial cell interposition with the GBM may be seen. This gives rise to the classic splitting of tramtracking of the GBM.

 

 

Membranoproliferative glomerulonephritis, type I 
   

Image 2 of 3
A few of these electron dense deposits are seen in the mesangial matrix.

 

 

 

 

Membranoproliferative glomerulonephritis, type I 
   

Image 3 of 3
The foot processes of the visceral epithelial cells show fusion. This image also exhibits glomerular capillary wall reduplication (splitting) with circumferential mesangial cell interposition between the basement membrane.

 

Membranoproliferative glomerulonephritis, type I 

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