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Electron Microscopy for Pathologists: Muscle Pathology
H2. Nemaline Inclusion Myopathy continued
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Image 3 of 5 Nemalin rods
can be present as dense, irregular bodies in a random orientation
just beneath the sarcolemma. On electron microscopy, they present
as thickenings of the Z-lines within Type I fibers.
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Image 4 of 5 The nemalin
rods are actually derived from Z-band material and have been
characterized immunohistochemically with anti-alpha-actinin.
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Image 5 of 5 At higher
magnification, nemalin rods show variable rod length in the
longitudinal section. Thin filaments extending from each end
interdigitate with thicker filaments.
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