Slide 2.21
Low power view showing sclerosis of para-glomerular arterioles in kidney; another renal complication of diabetes. Glomerulosclerosis and arteriosclerosis lead to tubular ischemia, and the kidney will undergo tubular atrophy, interstitial fibrosis, and become non-functional.

Slide 2.22
High power view of diabetic glomerulopathy or Kimmelstiel-Wilson disease. Note the ovoid, hyaline masses present within the mesangium and surrounded by patent capillary loops. These nodules contain lipids and fibrin. As these lesions progress they will close down the capillaries and destroy the glomerulus.