Slide
1
As the crypt abscesses
of ulcerative colitis increase in size, they undermine the adjacent
mucosa, which sloughs to form numerous, closely placed, shallow
ulcers covered by fibrinopurulent exudate (U). Note that the ulcers
do not penetrate into the muscularis propria. Almost total
ulceration occurs in severe cases, in which the surface is intensely
hemorrhagic. The healing of extensively ulcerated areas is initiated
by granulation tissue. Residual inflamed mucosa and exuberant
granulation tissue often form nodules elevated above the surrounding
mucosa that are called "inflammatory pseudopolyps" (P). |
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