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Gastrointestinal
Pathology for Medical II Students Lab 3a Normal Liver (56000-01000)
Slide
1
The hepatic architecture may be
anatomically defined (the classic hepatic lobule) or functionally
defined (Rappaport's acinus). The classic hepatic lobule consists of
a central vein (C) with its surrounding hepatocytes and 4-6 portal
tracts (P). The hepatic plates are typically one cell thick and
radiate away from the central vein like spokes of a wheel. |
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Slide
2
Each portal tract should contain
a bile duct (BD) lined by a single layer of cuboidal or columnar
cells, a branch of the hepatic artery (A) and a branch of the portal
vein (V), all of which are invested by fibrous stroma. Scattered
chronic inflammatory cells are normally found within the portal
tracts and unless significantly increased they are of no importance. |
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Slide
3
The hepatocytes are typically
arranged in single cell plates. They are large polygonal cells with
granular, eosinophilic cytoplasm and round, vesicular nuclei that are
often nucleolated. The smallest biliary radicles, the canaliculi, are
formed by the apposing plasma membranes of two adjacent hepatocytes.
The sinusoids are lined by endothelial cells and Kupffer cells.
Kupffer cells are derived from the monocyte- macrophage system and are
actively phagocytic. They are larger than the endothelial cells and
often have a bean-shaped nucleus. If you have a good eye, you should
be able to identify them in your slide of normal liver. They become
much more prominent when they contain phagocytosed material and you
will be able to see them very well in your example of hemochromatosis. |
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Digital Legends
for Labs/Cases
Lab 1
1.a | 1.b | 1.c | 1.d | 1.e | 1.f | 1.g | 1.h | 1.i | 1.j | 1.k | 1.l | 1.m
Lab 2
2.a | 2.b | 2.c | 2.d | 2.e | 2.f | 2.g | 2.h | 2.i | 2.j | 2.k | 2.l | 2.m
Lab 3
3.a | 3.b | 3.c | 3.d | 3.e | 3.f | 3.g | 3.h | 3.i | 3.j | 3.k | 3.l
Medical II
Updated
March 2, 2007
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