Slide 4 

With time, the cholestasis progresses and may be seen in the periportal parenchyma.  Occasionally, focal collections of dead, bile stained hepatocytes may be seen.  These are called bile infarcts (arrow).  They are usually seen in the periportal parenchyma.

Slide 5

Shows a higher magnification a periportal bile infarct.  After several weeks of unrelieved obstruction, bile ductular proliferation (arrows) may be seen.  With time there is progressive portal fibrosis.  Eventually, these fibrous septa link to completely circumscribe islands of hepatic parenchyma and the patient will develop cirrhosis.