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Gastrointestinal
Pathology for Medical II Students Lab 3g Alcoholic
hepatitis with Early Cirrhosis (56000-48500-E5512)
These sections were taken from a
patient with chronic alcoholic liver disease.
Slide
1
The hepatic architecture is
disturbed by portal and sinusoidal (pericellular) fibrosis. Some of
the fibrous bands are just beginning to link-up to circumscribe
nodules of hepatic parenchyma. This patient not only has very early
cirrhosis but also acute alcoholic hepatitis. |
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Slide
2
Shows portal fibrosis (f) as well
as pericellular fibrosis at higher power. |
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Slide
3
Shows prominent pericellular
fibrosis (individual and small clusters of hepatocytes completely
surrounded by fibrous tissue). This sinusoidal or pericellular
fibrosis is usually most severe in centrilobular regions and is a
common feature of alcoholic hepatitis. Note that many of the
hepatocytes contain Mallory bodies. |
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Slide
4
Mallory bodies (arrow) appear
as violaceous, ropy, hyaline inclusions located in the perinuclear
region of the cytoplasm of the hepatocytes. They are composed of
degenerated intermediate (cytokeratin) filaments of the cytoskeleton
of the liver cells. Mallory bodies are chemotactic for polys and
polymorphonuclear inflammation is characteristic of alcoholic
hepatitis. As a matter of fact, some investigators feel that enzymes
released by polymorphonuclear leukocytes may be responsible for the
pericellular fibrosis seen in alcoholic liver disease. You will
remember that the inflammation in acute viral hepatitis, on the other
hand, is predominantly mononuclear. |
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Digital Legends
for Labs/Cases
Lab 1
1.a | 1.b | 1.c | 1.d | 1.e | 1.f | 1.g | 1.h | 1.i | 1.j | 1.k | 1.l | 1.m
Lab 2
2.a | 2.b | 2.c | 2.d | 2.e | 2.f | 2.g | 2.h | 2.i | 2.j | 2.k | 2.l | 2.m
Lab 3
3.a | 3.b | 3.c | 3.d | 3.e | 3.f | 3.g | 3.h | 3.i | 3.j | 3.k | 3.l
Medical II
Updated
March 2, 2007
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