Slide 5

If you look carefully you may be able to find ongoing apoptosis of infected hepatocytes.  The arrow indicates an acidophilic body.

Slide 6

You may be puzzled to note that many of the hepatocytes within the center of the regenerative nodules are shrunken and more eosinophilic.  These centrally located hepatocytes have undergone ischemic necrosis.  You will recall from your syllabus that the fibrosis and regenerative nodules of cirrhosis destroy the hepatic architecture and disrupt blood flow through the liver.  Often the hepatocytes at the center of the regenerative nodules are only marginally supplied with blood.  Should the patient suffer a hypotensive episode, as typically occurs from bleeding esophageal varices, the centers of the regenerative nodules will infarct.

Slide 7

Shows at higher power, the demarcation between the peripherally located, viable (V) hepatocytes and the more centrally located, necrotic (N) hepatocytes.