Hematology/Oncology Lymph Node Seminar for Medical II Students

Slides 1D-F Normal Lymph Node with Reactive Follicular Hyperplasia

Identify:

• capsule
• subcapsular sinus
• follicles (germinal centers and mantle zones)
• interfollicular zone (paracortex)
• medullary sinuses (sinuses are more easily identified on slide 7)
• B-cell and T-cell areas of the lymph node

Discussion:

1. What architectural changes occur with reactive processes in the lymph nodes?
2. Compare the pattern expected from a predominantly B-cell reaction (humoral immune response) with a predominantly T-cell process (cell-mediated immune response).

Slides D & E | Slide F

Slide D subcapsular sinus and paracortex
Slide E medullary cords and sinuses. Between the medullary sinuses are the medullary cords which are packed with lymphocytes and plasma cells. The sinuses contain histiocytes, lymphocytes, and plasma cells.

Digital Legends for Labs
Slides 1a-c | Slides 1d-f | Slides 2a-d | Slides 3a-c | Slides 3d-f | Slides 4a-c | Slides 5a-c 
Slides 5d-e | Slides 6a-b | Slides 7a-b

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Updated October 1, 2007