Lymph Node Seminar for Medical II Students

Slides 3D-G Cervical Lymph Node Biopsy

This is a cervical lymph node biopsy from a 61- year- old female with non-tender, firm, enlarged lymph nodes in the cervical and axillary regions, bilaterally. Her spleen and liver are not enlarged. 

Laboratory results include: 

• Hgb. 8.0 g/dl
• Hct. 31%
• WBC 7,000 1

Chest X-ray: unremarkable. CT scan of the abdomen revealed enlarged para-aortic lymph nodes, bilaterally.

Discussion:

1. What architectural changes are present in this biopsy?
2. What size are the cells (small, intermediate, or large)?
3. What is your diagnosis?
4. Is this disorder more likely to be of a B-cell of a T-cell origin?
5. A bone marrow biopsy from this patient has an infiltrate of cells similar to those in the lymph node biopsy. Is this unusual?
6. If the patient had a lymphocytosis of 20,000 in the peripheral blood, what would her diagnosis have been?

Slides D & E | Slides F & G

Slide F A fine needle aspirate from the cervical lymph node. The intact cells have the appearance of small lymphocytes.

Slide G Four different types of lymphoma at the same magnification. A. Non-Hodgkin's lymphoma, small lymphocytic. These cells are indistinguishable from normal lymphocytes. B. Non-Hodgkin's lymphoma, small cleaved lymphocytic. These cells are still small, but show irregular, or "cleaved" nuclei. C. Burkitt's lymphoma. These cells are intermediate in size between frames A and D. A normal histiocyte is present on the right side. D. Non-Hodgkin's lymphoma, large cell. Compare with frame B.

Digital Legends for Labs
Slides 1a-c | Slides 1d-f | Slides 2a-d | Slides 3a-c | Slides 3d-f | Slides 4a-c | Slides 5a-c 
Slides 5d-e | Slides 6a-b | Slides 7a-b

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Updated October 1, 2007