Musculoskeletal and Skin Pathology for Medical II Students

Gross Pathologic and Radiographic Features of Selected Specimens of Bone

H. Clavicle with Ewing's Sarcoma

Slide 1
The gross appearance suggests an intramedullary tumor that has lysed much of the cortical bone and extended out into the soft tissue where it probably caused a palpable swelling and local tenderness. On your histopathological examinations, you saw how this tumor infiltrated the adjacent muscle. The radiograph shows very well the lytic process and soft tissue mass and perhaps small pieces of bone that you saw in your sections. It's not certain whether these are bone fragments that were not lysed or whether they represent reactive bone formation.

tumor

Slide 2
Radiograph of a highly permeative destructive process involving the distal clavicle. The permeative destruction and relatively large soft tissue mass are characteristic of the aggressive Ewing's sarcoma. This lesion has a predilection for the diaphyses of long bones, unlike the osteosarcoma which tends to be located in the metaphyseal regions.

sarcoma

Digital Legends for Labs/Cases
Lab 1
1a | 1b | 1c | 1d | 1e | 1f | 1g
Gross & Radiographs
a | b | c | d | e | f | g | h 
Lab 2
2a | 2b | 2c | 2d | 2e | 2f

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Updated August 28, 2007