Musculoskeletal and Skin Pathology for Medical II Students

Lab 2b Scleroderma (03000-48210)

Thickening or hardening of the skin can occur in a number of distinctive forms. Perhaps best known is the systemic disorder, scleroderma, in which there may also be involvement of internal organs such as the heart and kidney. A subset of scleroderma, the CREST syndrome, features calcinosis cutis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectases. Some characteristic antinuclear antibodies accompany these disorders. Less well known but probably much more common are the localized forms of scleroderma, also known as morphea. These present as firm, indurated plaques on the skin, often with a slightly dusky coloration or a "lilac-colored" border. Linear, deep-seated, and disseminated forms also occur. Slow resolution, sometimes with residual deformity, is the rule, but these patients typically do not have systemic abnormalities.

Slides D7a & D7b | Slides D8 & D9

Slide D7a Facial sclerosis in a patient with systemic scleroderma.
Slide D7b Isolated sclerotic plaque of morphea. This patient had no systemic manifestations of scleroderma.

Digital Legends for Labs/Cases
Lab 1
1a | 1b | 1c | 1d | 1e | 1f | 1g
Gross & Radiographs
a | b | c | d | e | f | g | h 
Lab 2
2a | 2b | 2c | 2d | 2e | 2f

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Updated August 28, 2007