Renal Pathology for Medical II Students

Lab 1.e Crescentic Glomerulonephritis

A number of different conditions can produce a crescentic glomerulonephrities including post-streptococcal disease, lupus erythematosus, Wegener's granulomatosis, and antiglomerular basement membrane disease. Clinically patients present with rapidly progressive deterioration of renal function. Early diagnosis is critical.

Slides 1.27 & 1.28

Slide 1.27
High power view. PAS stain.

glomerulonephritis
Slide 1.28
A single glomerulus being overwhelmed by crescent formation. Note the cellularity of the interstitium. Crescents are more difficult to appreciate in H/E stained sections as in this image.

 

glomerulus

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Updated August 2, 2007