Virginia Commonwealth University Service

2004- Present     Assistant Professor of Pathology, Division of Molecular Diagnostics
2006- Present     Director of the Molecular Morphology Genomics Facility

Education

School of Chemistry, National University of Córdoba, Córdoba, Argentina
Masters in Science, Biological Chemistry 1986 – 1990

School of Chemistry, National University of Córdoba, Córdoba, Argentina
PhD, Molecular Biology1992 – 1997

School of Chemistry, National University of Córdoba, Córdoba, Argentina
Postdoctoral fellowship of National Research Council (CONICET), Buenos Aires, Argentina 1998 – 2000

Virginia Commonwealth University, Richmond, VA
Postdoctoral Associate of Department of Pathology 2000 – 2001

Virginia Commonwealth University, Richmond, VA
Molecular Diagnostics Specialist: Department of Pathology 2001 – 2004

Honors and Awards

Association for Molecular Pathology
2002   Young Investigator Award, Supported by Motorola Life Science, Dallas, TX

VCU’s Massey Cancer Center
2003   Excellence in Cancer Research, 1st Place Award for Outstanding Poster Presentation at the 2003 Research Retreat, Richmond, VA

College of American Pathologists (CAP) Foundation
2004   CAP Foundation Conference Travel Award to attend APIII, Pittsburgh, PA

Professional Societies

Member of the Argentinean Society of Biochemical Research (SAIB)
Member of the Society of Biology of Córdoba (SBC)
Member of the Association for Molecular Pathology (AMP)
Member of the American Association for Cancer Research (AACR)
Observer to the National Committee for Clinical Laboratory Standards (NCCLS)
Member of the Association for Pathology Informatics (API)

Copyrights and Patents

Disclosure 06-63: “Quality control algorithm and template for gene expression microarray clinical applications” transferred to VCU-Intellectual Property Foundation.

Research Support

ACTIVE
Genes related to HCC progression in living donor and deceased donor transplant liver recipients.  Funding Source: NIH (Collaborator)
Dates of Approved/Proposed Project:  04/01/06 thru 03/31/11
Annual Direct Costs: $3,000,000 (Combined 3 yrs)

Effects of Developmental Stage and KLF2 on Mouse Erythroid Genetic Profiles.  Funding Source: NIH (Co-Investigator)
Dates of Approved/Proposed Project:  04/01/2007 thru 03/31/2010
Annual Direct Costs: $ 600,000 (combined 3 yrs)

Hepatic Oval Cells in Culture and In Vivo
Funding Source: NIH (Co-Investigator)
Dates of Approved/Proposed Project:  07/01/2007 thru 06/30/2012
Annual Direct Costs: $1,150,000 (Combined 5 yrs)

PENDING
Molecular targets of AKT signaling in childhood ependymoma
Funding Source: NIH (Co-Investigator)
Dates of Approved/Proposed Project:  04/01/2007 thru 03/31/2012
Annual Direct Costs: $1,175,000 (Combined 5 yrs)

Symposia, Seminars And Meetings As Invited Speaker Or Poster Presentations (Last 5 years)

Invited speaker at the Massey Cancer Center Research Seminars, Richmond, VA, 2004.

Invited speaker at the Department of Clinical Biochemistry, National University of Córdoba, Córdoba, Argentina, 2004.

Advancing Practice, Instruction And Innovation Through Informatics (APIII) Annual Conference held in Pittsburgh, PA, 2004.

Association for Molecular Pathology (AMP), Annual Meeting. Los Angeles, CA. 2004.

American Society of Hematology (ASH), 46th Annual Meeting. San Diego, CA. 2004.

United States and Canadian Academy of Pathology (USCAP), 94th Annual Meeting, San Antonio, TX, 2005.

Association for Molecular Pathology (AMP), Annual Meeting. Scottsdale, AZ. 2005.

XLI Annual Meeting of the Argentine Society for Biochemistry and Molecular Biology (SAIB). Pinamar, Buenos Aires, Argentina. 2005.

World Transplant Congress (WTC), Annual Meeting. Boston, MA. 2006.

Association for Molecular Pathology (AMP), Annual Meeting. Orlando, FL. 2006.

XLII Reunión Anual de la Sociedad Argentina de Investigación en Bioquímica y Biología Molecular (SAIB). Rosario, Santa Fe, Argentina. 2006.

Association for Molecular Pathology (AMP), Annual Meeting. Los Angeles, CA. 2007.

United States and Canadian Academy of Pathology Annual Meeting (USCAP). San Diego, CA. March 2007.

Association for Molecular Pathology (AMP), Annual Meeting. Grapevine, TX. 2008.

American Society of Cytopathology meeting in Orlando, FL 2008.

Invited Teacher at the Department of Clinical Biochemistry, National University of Córdoba, Córdoba, Argentina, 2008.

Invited Grand Rounds Speaker at the Department of Pathology at UPMC, Pittsburgh, PA, 2009.

Recent Publications (Last 5 years)

Monzon FA, Lyons-Weiler M, Buturovic LJ, Rigl CT, W. Henner D, Sciulli C, Dumur CI, Medeiros F, Anderson GG. Multicenter Validation of a 1550-Gene Expression Profile for Identification of Tumor Tissue of Origin. Journal of Clinical Oncology, in press.

Dumur CI, Ladd AC, Wright HV, Penberthy LT, Wilkinson DS, MD, Powers CN, Garrett CT, DiNardo, LJ. Genes involved in Radiation Therapy Response in Head and Neck Cancers. Laryngoscope, 2008;119(1):91-101.

Dumur CI, Sana S, Ladd AC, Ferreira-Gonzalez A, Wilkinson DS, Powers CN, Garrett CT. Assessing the impact of tissue devitalization time on genome-wide gene expression analysis in ovarian tumor samples. Diagnostic Molecular Pathology, 2008;17(4):200-206.

Mas VR, Archer KJ, Yanek K, Dumur CI, Capparuccini MI, Mangino MJ, King A, Fisher R, Posner M, Maluf D. Gene Expression Patterns in Deceased Donor Kidneys Developing Delayed Graft Function Post-Kidney Transplantation. Transplantation. 2008;85(4):626-635.

Redmond LC, Dumur CI, Archer KJ, Haar JL, Lloyd JA. Identification of erythroid-enriched gene expression in the mouse embryonic yolk sac using microdissected cells. Developmental Dynamics. 2008;237(2):436-446.

Dumur CI, Lyons-Weiler M, Sciulli C, Garrett CT, Schrijver I, Holley TK, Rodriguez-Paris J, Pollack JR, Zehnder JL, Price M, Hagenkord JM, Rigl CT, Buturovic LJ, Anderson GG, Monzon FA. Interlaboratory performance of a microarray-based gene expression test to determine tissue of origin in poorly differentiated and undifferentiated cancers. J Mol Diagn. 2008;10(1):67-77.

Archer KJ, Dumur CI, Taylor GS, Chaplin MD, Guiseppi-Elie A, Buck GA, Grant G, Ferreira-Gonzalez A, Garrett CT. A disattenuated correlation estimate when variables are measured with error: Illustration estimating cross-platform correlations. Statistics in Medicine 2008;27(7):1026-1039.

Archer KJ, Dumur CI, Taylor GS, Chaplin MD, Guiseppi-Elie A, Grant G, Ferreira-Gonzalez A, Garrett CT. Application of a correlation correction factor in a microarray cross-platform reproducibility study. BMC Bioinformatics. 2007;8(1):447.

Kmieciak M, Knutson KL, Dumur CI, Manjili MH. HER-2/neu antigen loss and relapse of mammary carcinoma are actively induced by T cell-mediated anti-tumor immune responses.  Eur J Immunol. 2007;37(3):675-85.

Mas VR, Fisher RA, Archer KJ, Yanek KC, Williams B, Dumur CI, Maluf DG. Genes associated with progression and recurrence of hepatocellular carcinoma in hepatitis C patients waiting and undergoing liver transplantation: preliminary results. Transplantation. 2007;83(7):973-81.

Van Meter TE*, Dumur CI*, Hafez N, Garrett CT, Fillmore H and Broaddus WC. Microarray Analysis of MRI-defined Tissue Samples in Glioblastoma Reveals Differences in Regional Expression of Therapeutic Targets..  Diagnostic Molecular Pathology 2006;15(4):195-205. (*) Authors contributed equally to this work.

Mas VR, Maluf DG, Dumur CI, Archer KJ, Yanek K, Jackson-Cook C, Fisher RA.  Molecular Techniques for Identifying HCC Origin and Biology After Orthotopic Liver Transplantation.  Diagnostic Molecular Pathology 2006;15(2):90-4.

Redmond LC, Haar JL, Giebel ML, Dumur CI, Basu P, Ware JL, Lloyd JA.  Isolation of Erythroid Cells from the Mouse Embryonic Yolk Sac by Laser Capture Microdissection and Subsequent Microarray Hybridization. Blood Cells, Molecules and Diseases, 2006;37(1):27-32.

Fossey SC, Ferreira-Gonzalez A, Garrett CT, Dumur CI, Vnencak-Jones CL.  BCRABL Transcript Detection by Quantitative Real-Time PCR: Are Correlated Results Possible from Homebrew Assays? Molecular Diagnostic 2005;9(4):187-193.

Archer KJ, Dumur CI, Joel SE and Ramakrishnan V.  Assessing RNA degradation in Affymetrix GeneChip experiments using mixed effect models. Biostatistics 2006;7(2):198–212.

Elmore LW, Di X, Dumur C, Holt SE and Gewirtz DA.  Evasion of a single step, chemotherapy-induced senescence in breast cancer cells: implications for treatment response.  Clinical Cancer Research 2005;11(7):2637-2643.

Dumur CI, Nasim S, Best AM, Archer KJ, Ladd AC, Mas VR, David S. Wilkinson DS, Garrett CT, Ferreira-Gonzalez A.  Evaluation of Quality Control Parameters for Microarray Gene Expression Analysis.  Clinical Chemistry 2004;50(11):1994-2002.

Archer KJ, Dumur CI and Ramakrishnan V.  Graphical technique for identifying a monotonic variance stabilizing transformation for absolute gene intensity signals.  BMC Bioinformatics 2004;5: 60-68.

Mas VR, Maluf DG, Stravitz R, Dumur CI, Clark B, Rodgers C, Ferreira-Gonzalez A, Fisher RA.  Hepatocellular Carcinoma (HCC) in HCV-infected liver transplant recipients: Genes involved in tumor progression.  Liver Transplantation 2004;10(5):607–620.

Dumur CI, Garrett CT, Archer KJ, Nasim S, Wilkinson DS and Ferreira-Gonzalez A.  Evaluation of a Linear Amplification Method for Small Samples Used on High Density Oligonucleotide Microarray Analysis.  Analytical Biochemistry 2004;331(2):314-321.

Dumur CI, Dechsukhum C, Ware JL, Cofield S, Best A, Wilkinson DS, Garrett CT and Ferreira-Gonzalez A.  Genome-wide Detection of LOH in Prostate Cancer Using Human SNP Microarray Technology. Genomics 2003;81(3):260-269.

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Updated January 16, 2009