Catherine I. Dumur, Ph.D.
Assistant Professor of Pathology
Department of Pathology
Virginia Commonwealth University
July 2004 - Present
Office: (804) 828-9564
cdumur@mcvh-vcu.edu
Assistant Professor of Pathology
Department of Pathology
Virginia Commonwealth University
July 2004 - Present
Office: (804) 828-9564
cdumur@mcvh-vcu.edu
Virginia Commonwealth University Service
2004- Present Assistant Professor of Pathology, Division of Molecular Diagnostics
2006- Present Director of the Molecular Morphology Genomics Facility
Education
School of Chemistry, National University of Córdoba, Córdoba, Argentina
Masters in Science, Biological Chemistry 1986 – 1990School of Chemistry, National University of Córdoba, Córdoba, Argentina
PhD, Molecular Biology1992 – 1997School of Chemistry, National University of Córdoba, Córdoba, Argentina
Postdoctoral fellowship of National Research Council (CONICET), Buenos Aires, Argentina 1998 – 2000Virginia Commonwealth University, Richmond, VA
Postdoctoral Associate of Department of Pathology 2000 – 2001Virginia Commonwealth University, Richmond, VA
Molecular Diagnostics Specialist: Department of Pathology 2001 – 2004
Honors and Awards
Association for Molecular Pathology
2002 Young Investigator Award, Supported by Motorola Life Science, Dallas, TXVCU’s Massey Cancer Center
2003 Excellence in Cancer Research, 1st Place Award for Outstanding Poster Presentation at the 2003 Research Retreat, Richmond, VACollege of American Pathologists (CAP) Foundation
2004 CAP Foundation Conference Travel Award to attend APIII, Pittsburgh, PA
Professional Societies
Member of the Argentinean Society of Biochemical Research (SAIB)
Member of the Society of Biology of Córdoba (SBC)
Member of the Association for Molecular Pathology (AMP)
Member of the American Association for Cancer Research (AACR)
Observer to the National Committee for Clinical Laboratory Standards (NCCLS)
Member of the Association for Pathology Informatics (API)
Copyrights and Patents
Disclosure 06-63: “Quality control algorithm and template for gene expression microarray clinical applications” transferred to VCU-Intellectual Property Foundation.
Research Support
ACTIVE
Validation of Pathwork Oncology Suite: Tissue of Origin Test
Funding Source: University of Pittsburgh/Pathwork, SRA (PI)
Dates of Approved/Proposed Project: 6/6/06 thru 4/30/07
Annual Direct Costs: $24,973.00Tumor Genetic Profiling: New predictive assays for breast cancer therapy
Funding Source: V-Foundation (Co-Investigator)
Dates of Approved/Proposed Project: 11/01/04 thru 10/31/07
Annual Direct Costs: $300,000 (combined 3 yrs)Improving Metrics for Monitoring the Therapeutic Effectiveness of Radiation Treatment in Head and Neck Tumors
Funding Source: Richmond Eye and Ear Foundation (Co-PI)
Dates of Approved/Proposed Project: 07/10/2006 thru 07/09/2007
Annual Direct Costs: $49,317Guidance of Oligodendrocyte Processes: The Role of Local Protein Synthesis.
Funding Source: NIH (Co-Investigator)
Dates of Approved/Proposed Project: 12/01/2006 thru 11/30/2008
Annual Direct Costs: $275,000 (combined 2 yrs)A Molecular Signature for Progression of Pediatric Optic Glioma
Funding Source: Musella Foundation (Co-Investigator)
Dates of Approved/Proposed Project: 01/01/2007 thru 12/31/2007
Annual Direct Costs: $100,000Genes related to HCC progression in living donor and deceased donor transplant liver recipients. Funding Source: NIH (Collaborator)
Dates of Approved/Proposed Project: 04/01/06 thru 03/31/11
Annual Direct Costs: $3,000,000 (Combined 3 yrs)PENDING
Effects of Developmental Stage and KLF2 on Mouse Erythroid Genetic Profiles. Funding Source: NIH (Co-Investigator)
Dates of Approved/Proposed Project: 04/01/2007 thru 03/31/2010
Annual Direct Costs: $ 600,000 (combined 3 yrs)Hepatic Oval Cells in Culture and In Vivo
Funding Source: NIH (Co-Investigator)
Dates of Approved/Proposed Project: 07/01/2007 thru 06/30/2012
Annual Direct Costs: $1,150,000 (Combined 5 yrs)DNA Damage and Recovery in Breast Cancer Cells after Chemotherapy
Funding Source: ACS (Co-Investigator)
Dates of Approved/Proposed Project: 07/01/2007 thru 06/30/2011
Annual Direct Costs: $568,075(Combined 4 yrs)Genome-Wide gene expression profiling for predicting the therapeutic effectiveness of chemoradiotherapy treatment in head and neck squamous cell carcinomas
Funding Source: Kimmel Foundation (PI)
Dates of Approved/Proposed Project: 07/01/2007 thru 06/30/2009
Annual Direct Costs: $172,603 (Combined 2 yrs); Path Dept: direct costs: $157,416Molecular targets of AKT signaling in childhood ependymoma
Funding Source: NIH (Co-Investigator)
Dates of Approved/Proposed Project: 04/01/2007 thru 03/31/2012
Annual Direct Costs: $1,175,000 (Combined 5 yrs)
Symposia, Seminars And Meetings As Invited Speaker Or Poster Presentations (Last 5 years)
United States and Canadian Academy of Pathology (USCAP), 91st Annual Meeting, Chicago, IL. 2002.
Oncogenomics 2002: Dissecting Cancer through Genome Research, an AACR Special Conference. Dublin, Ireland. 2002.
Association for Molecular Pathology (AMP), Annual Meeting. Dallas, TX. 2002.
American Association for Cancer Research (AACR), 94th Annual Meeting, Washington, DC. 2003. WT1 Expression and Function in Ovarian Cancer Cells. Dumur CI, Atkins KA, Ferreira-Gonzalez A, Garrett CT, Kalli KR, Roberts CT, Conover CA, Ware JL.
Association for Molecular Pathology (AMP), Annual Meeting. Orlando, FL. 2003.
Invited speaker at the University of Pittsburgh, Department of Pathology, Division of Pathology and Oncology Informatics. Pittsburgh, PA, 2004.Invited speaker at the Massey Cancer Center Research Seminars, Richmond, VA, 2004.
Invited speaker at the Department of Clinical Biochemistry, National University of Córdoba, Córdoba, Argentina, 2004.Advancing Practice, Instruction And Innovation Through Informatics (APIII) Annual Conference held in Pittsburgh, PA, 2004.
Association for Molecular Pathology (AMP), Annual Meeting. Los Angeles, CA. 2004.
American Society of Hematology (ASH), 46th Annual Meeting. San Diego, CA. 2004.
United States and Canadian Academy of Pathology (USCAP), 94th Annual Meeting, San Antonio, TX, 2005.
Association for Molecular Pathology (AMP), Annual Meeting. Scottsdale, AZ. 2005.
XLI Annual Meeting of the Argentine Society for Biochemistry and Molecular Biology (SAIB). Pinamar, Buenos Aires, Argentina. 2005.
World Transplant Congress (WTC), Annual Meeting. Boston, MA. 2006.
Association for Molecular Pathology (AMP), Annual Meeting. Orlando, FL. 2006.
XLII Reunión Anual de la Sociedad Argentina de Investigación en Bioquímica y Biología Molecular (SAIB). Rosario, Santa Fe, Argentina. 2006.
Recent Publications (Last 5 years)
Redmond LC, Dumur CI, Archer KJ, Haar JL, Lloyd JA. Identification of erythroid-enriched gene expression in the mouse embryonic yolk sac using microdissected cells. Dev Dyn. 2008;237(2):436-46.
Dumur CI, Lyons-Weiler M, Sciulli C, Garrett CT, Schrijver I, Holley TK, Rodriguez-Paris J, Pollack JR, Zehnder JL, Price M, Hagenkord JM, Rigl CT, Buturovic LJ, Anderson GG, Monzon FA. Interlaboratory performance of a microarray-based gene expression test to determine tissue of origin in poorly differentiated and undifferentiated cancers. J Mol Diagn. 2008;10(1):67-77. Epub 2007 Dec 13.
Archer KJ, Dumur CI, Taylor GS, Chaplin MD, Guiseppi-Elie A, Grant G, Ferreira-Gonzalez A, Garrett CT. Application of a correlation correction factor in a microarray cross-platform reproducibility study. BMC Bioinformatics. 2007;8:447.
Archer KJ, Dumur CI, Taylor GS, Chaplin MD, Guiseppi-Elie A, Buck GA, Grant G, Ferreira-Gonzalez A, Garrett CT. A disattenuated correlation estimate when variables are measured with error: Illustration estimating cross-platform correlations. Stat Med. 2008;27(7):1026-39.
Mas VR, Fisher RA, Archer KJ, Yanek KC, Williams B, Dumur CI, Maluf DG. Genes associated with progression and recurrence of hepatocellular carcinoma in hepatitis C patients waiting and undergoing liver transplantation: preliminary results. Transplantation. 2007;83(7):973-81.
Kmieciak M, Knutson KL, Dumur CI, Manjili MH. HER-2/neu antigen loss and relapse of mammary carcinoma are actively induced by T cell-mediated anti-tumor immune responses. Eur J Immunol. 2007;37(3):675-85.
Van Meter T, Dumur C, Hafez N, Garrett C, Fillmore H, Broaddus WC. Microarray analysis of MRI-defined tissue samples in glioblastoma reveals differences in regional expression of therapeutic targets. Diagn Mol Pathol. 2006;15(4):195-205.
Mas VR, Maluf DG, Dumur CI, Archer KJ, Yanek K, Jackson-Cook C, Fisher RA. Molecular techniques for identifying HCC origin and biology after orthotopic liver transplantation. Diagn Mol Pathol. 2006;15(2):90-4.
Redmond LC, Haar JL, Giebel ML, Dumur CI, Basu P, Ware JL, Lloyd JA. Isolation of erythroid cells from the mouse embryonic yolk sac by laser capture microdissection and subsequent microarray hybridization. Blood Cells Mol Dis. 2006;37(1):27-32. Epub 2006 May 12.
Fossey SC, Ferreira-Gonzalez A, Garrett CT, Dumur CI, Vnencak-Jones CL. BCRABL transcript detection by quantitative real-time PCR: are correlated results possible from homebrew assays? Mol Diagn. 2005;9(4):187-93.
Archer KJ, Dumur CI, Joel SE, Ramakrishnan V. Assessing quality of hybridized RNA in Affymetrix GeneChip experiments using mixed-effects models. Biostatistics. 2006;7(2):198-212. Epub 2005 Aug 31.
Elmore LW, Di X, Dumur C, Holt SE, Gewirtz DA. Evasion of a single-step, chemotherapy-induced senescence in breast cancer cells: implications for treatment response. Clin Cancer Res. 2005;11(7):2637-43.
Dumur CI, Nasim S, Best AM, Archer KJ, Ladd AC, Mas VR, Wilkinson DS, Garrett CT, Ferreira-Gonzalez A. Evaluation of quality-control criteria for microarray gene expression analysis. Clin Chem. 2004;50(11):1994-2002. Epub 2004 Sep 13.
Dumur CI, Garrett CT, Archer KJ, Nasim S, Wilkinson DS, Ferreira-Gonzalez A. Evaluation of a linear amplification method for small samples used on high-density oligonucleotide microarray analysis. Anal Biochem. 2004;331(2):314-21.
Archer KJ, Dumur CI, Ramakrishnan V. Graphical technique for identifying a monotonic variance stabilizing transformation for absolute gene intensity signals. BMC Bioinformatics. 2004;5:60.
Mas VR, Maluf DG, Stravitz R, Dumur CI, Clark B, Rodgers C, Ferreira-Gonzalez A, Fisher RA. Hepatocellular carcinoma in HCV-infected patients awaiting liver transplantation: genes involved in tumor progression. Liver Transpl. 2004;10(5):607-20.
Dumur CI, Dechsukhum C, Ware JL, Cofield SS, Best AM, Wilkinson DS, Garrett CT, Ferreira-Gonzalez A. Genome-wide detection of LOH in prostate cancer using human SNP microarray technology. Genomics. 2003;81(3):260-9.
Updated February 21, 2008