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Catherine I. Dumur, PhD

Catherine I. Dumur, PhDAssociate Professor of Pathology
Department of Pathology
Virginia Commonwealth University
July 2004 - Present
Office: (804) 828-9564
cdumur@mcvh-vcu.edu

 

Education | Awards | VCU/MCV Appointments | Professional Service |
Recent Invited Presentations
| Recent Publications


Education


Postgraduate Medical Education

Molecular Diagnostics Specialist
Department of Pathology
Virginia Commonwealth University
Richmond, VA
2001 – 2004

Postdoctoral Associate
Department of Pathology
Virginia Commonwealth University
Richmond, VA
2000 – 2001

Postdoctoral fellowship of National Research Council (CONICET)
School of Chemistry
National University of Córdoba
Córdoba, Argentina
Buenos Aires, Argentina
1998 – 2000

Graduate Education

PhD, Molecular Biology
School of Chemistry
National University of Córdoba
Córdoba, Argentina
1992 – 1997

Masters in Science, Biological Chemistry
School of Chemistry
National University of Córdoba
Córdoba, Argentina
1986 – 1990


Awards

VCU School of Medicine
Educational Innovation Award, presented to the Molecular Diagnostics Practicum Academic Unit faculty members, Richmond, VA, 2010  

College of American Pathologists (CAP) Foundation
CAP Foundation Conference Travel Award to attend APIII, Pittsburgh, PA, 2004  

VCU’s Massey Cancer Center
Excellence in Cancer Research, 1st Place Award for Outstanding Poster Presentation at the 2003 Research Retreat, Richmond, VA, 2003  

Association for Molecular Pathology
Young Investigator Award, Supported by Motorola Life Science, Dallas, TX, 2002 

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Virginia Commonwealth University and Medical Center Appointments

Associate Professor of Pathology, Division of Anatomic Pathology
Associate Director of the Molecular Diagnostics Laboratory
Director of the Molecular Morphology Genomics Facility
Co-Director of the Tissue and data Acquisition and Analysis Core (TDAAC)


Professional Service

Member of the Argentinean Society of Biochemical Research (SAIB)
Member of the Society of Biology of Córdoba (SBC)
Member of the Association for Molecular Pathology (AMP)
Member of the American Association for Cancer Research (AACR)
Observer to the National Committee for Clinical Laboratory Standards (NCCLS)
Member of the Association for Pathology Informatics (API)


Recent Invited Presentations

Invited Grand Rounds Speaker at the Department of Pathology at UPMC, Pittsburgh, PA, 2009.

Invited Teacher at the Department of Clinical Biochemistry, National University of Córdoba, Córdoba, Argentina, 2008.

American Society of Cytopathology meeting in Orlando, FL 2008.

Association for Molecular Pathology (AMP), Annual Meeting. Grapevine, TX. 2008.

United States and Canadian Academy of Pathology Annual Meeting (USCAP). San Diego, CA. March 2007.

Association for Molecular Pathology (AMP), Annual Meeting. Los Angeles, CA. 2007.

XLII Reunión Anual de la Sociedad Argentina de Investigación en Bioquímica y Biología Molecular (SAIB). Rosario, Santa Fe, Argentina. 2006.

Association for Molecular Pathology (AMP), Annual Meeting. Orlando, FL. 2006.

World Transplant Congress (WTC), Annual Meeting. Boston, MA. 2006.

XLI Annual Meeting of the Argentine Society for Biochemistry and Molecular Biology (SAIB). Pinamar, Buenos Aires, Argentina. 2005.

Association for Molecular Pathology (AMP), Annual Meeting. Scottsdale, AZ. 2005.

United States and Canadian Academy of Pathology (USCAP), 94th Annual Meeting, San Antonio, TX, 2005.

American Society of Hematology (ASH), 46th Annual Meeting. San Diego, CA. 2004.

Association for Molecular Pathology (AMP), Annual Meeting. Los Angeles, CA. 2004.

Advancing Practice, Instruction And Innovation Through Informatics (APIII) Annual Conference held in Pittsburgh, PA, 2004.

Invited speaker at the Department of Clinical Biochemistry, National University of Córdoba, Córdoba, Argentina, 2004.

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Recent and Relevant Publications

Dr. Dumur “h-index” (JE Hirsch, PNAS 2005; 102:16569-16572 and P Ball, Nature 2007; 448:737) is 53 (which is the equivalent as saying 53 manuscripts, each of which have 53 citations or more) as calculated by ISI Web of Knowledge.

Li Y, Padmanabha D, Gentile LB, Dumur CI, Beckstead RB, Baker KD. HIF- and non-HIF-regulated hypoxic responses require the estrogen-related receptor in Drosophila melanogaster. PLoS Genet. 2013;9(1):e1003230.PMID: 23382692; PMCID: PMC3561118.

Romero N, Dumur CI, Martinez H, García IA, Monetta P, Slavin I, Sampieri L, Koritschoner N, Mironov AA, De Matteis MA, Alvarez C. Rab1b overexpression modifies Golgi size and gene expression in HeLa cells and modulates the thyrotrophin response in thyroid cells in culture. Mol Biol Cell. 2013;24(5):617-32. PMID:23325787; PMCID: PMC3583665.

Gehrau RC, Mas VR, Villamil FG, Dumur CI, Mehta NK, Suh JL, Maluf DG. MicroRNA Signature at the Time of Clinical HCV Recurrence Associates With Aggressive Fibrosis Progression Post-Liver Transplantation. Am J Transplant. 2013;13(3):729-37. PMID: 23312020.

Mas VR, Dumur CI, Scian MJ, Gehrau RC, Maluf DG. MicroRNAs as biomarkers in solid organ transplantation. Am J Transplant. 2013;13(1):11-9. PMID: 23136949.
Dumur CI, Idowu MO, Powers CN. Targeting tyrosine kinases in cancer: The converging roles of cytopathology and molecular pathology in the era of genomic medicine. Cancer Cytopathol. 2013;121(2):61-71. PMID: 22887782.

Srivastava J, Siddiq A, Emdad L, Santhekadur PK, Chen D, Gredler R, Shen XN, Robertson CL, Dumur CI, Hylemon PB, Mukhopadhyay ND, Bhere D, Shah K, Ahmad R, Giashuddin S, Stafflinger J, Subler MA, Windle JJ, Fisher PB, Sarkar D. Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model. Hepatology. 2012;56(5):1782-91. PMID: 22689379; PMCID: PMC3449036.

Zhao M, Sachs PC, Wang X, Dumur CI, Idowu MO, Robila V, Francis MP, Ware J, Beckman M, Rizki A, Holt SE, Elmore LW. Mesenchymal stem cells in mammary adipose tissue stimulate progression of breast cancer resembling the basal-type. Cancer Biol Ther. 2012;13(9):782-92. PMID: 22669576; PMCID: PMC3399703.

Campbell DJ, Dumur CI, Lamour NF, Dewitt JL, Sirica AE. Novel organotypic culture model of cholangiocarcinoma progression. Hepatol Res. 2012;42(11):1119-30. PMID: 22568523; PMCID: PMC3416930.

Pang CJ, Lemsaddek W, Alhashem YN, Bondzi C, Redmond LC, Ah-Son N, Dumur CI, Archer KJ, Haar JL, Lloyd JA, Trudel M. Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis. Mol Cell Biol. 2012;32(13):2628-44. PubMed PMID: 22566683; PMCID: PMC3434496.

Mas VR, Archer KJ, Dumur CI, Scian MJ, Suh JL, King AL, Wardius ME, Straub JA, Posner MP, Brayman K, Maluf DG. Reduced expression of inflammatory genes in deceased donor kidneys undergoing pulsatile pump preservation. PLoS One. 2012;7(4):e35526. PubMed PMID: 22545113; PMCID: PMC3335841.

Van DN, Roberts CF, Marion JD, Lépine S, Harikumar KB, Schreiter J, Dumur CI, Fang X, Spiegel S, Bell JK. Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics. FASEB J. 2012;26(8):3188-98. PMID: 22532440; PMCID: PMC3405273.

Chidambaram A, Fillmore HL, Van Meter TE, Dumur CI, Broaddus WC. Novel report of expression and function of CD97 in malignant gliomas: correlation with Wilms tumor 1 expression and glioma cell invasiveness. J Neurosurg. 2012;116(4):843-53. PMID: 22313360.

Idowu MO, Kmieciak M, Dumur C, Burton RS, Grimes MM, Powers CN, Manjili MH. CD44(+)/CD24(-/low) cancer stem/progenitor cells are more abundant in triple-negative invasive breast carcinoma phenotype and are associated with poor outcome. Hum Pathol. 2012;43(3):364-73. PMID: 21835433.

Ascierto ML, Kmieciak M, Idowu MO, Manjili R, Zhao Y, Grimes M, Dumur C, Wang E, Ramakrishnan V, Wang XY, Bear HD, Marincola FM, Manjili MH. A signature of immune function genes associated with recurrence-free survival in breast cancer patients. Breast Cancer Res Treat. 2012;131(3):871-80. PMID: 21479927; PubMed PMCID: PMC3431022.

Vaughan C, Mohanraj L, Singh S, Dumur CI, Ramamoorthy M, Garrett CT, Windle B, Yeudall WA, Deb S, Deb SP. Human Oncoprotein MDM2 Up-regulates Expression of NF-κB2 Precursor p100 Conferring a Survival Advantage to Lung Cells. Genes Cancer. 2011;2(10):943-55. PMID: 22701761; PMCID: PMC3374626.

Dumur CI, Fuller CE, Blevins TL, Schaum JC, Wilkinson DS, Garrett CT, Powers CN. Clinical verification of the performance of the pathwork tissue of origin test: utility and limitations. Am J Clin Pathol. 2011;136(6):924-33. PMID: 22095379.

Singh SK, Bhardwaj R, Wilczynska KM, Dumur CI, Kordula T. A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40. J Biol Chem. 2011;286(46):39893-903. PMID: 21953450; PubMed PMCID: PMC3220556.

Drake JI, Bogaard HJ, Mizuno S, Clifton B, Xie B, Gao Y, Dumur CI, Fawcett P, Voelkel NF, Natarajan R. Molecular signature of a right heart failure program in chronic severe pulmonary hypertension. Am J Respir Cell Mol Biol. 2011;45(6):1239-47. PMID: 21719795; PMCID: PMC3361357.

Redmond LC, Dumur CI, Archer KJ, Grayson DR, Haar JL, Lloyd JA. Krüppel-like factor 2 regulated gene expression in mouse embryonic yolk sac erythroid cells. Blood Cells Mol Dis. 2011;47(1):1-11. PMID: 21530336; PMCID: PMC3150518.

Sirica AE, Campbell DJ, Dumur CI. Cancer-associated fibroblasts in intrahepatic cholangiocarcinoma. Curr Opin Gastroenterol. 2011;27(3):276-84. Review. PMID: 21297470.

Ladd AC, O'Sullivan-Mejia E, Lea T, Perry J, Dumur CI, Dragoescu E, Garrett CT, Powers CN. Preservation of fine-needle aspiration specimens for future use in RNA-based molecular testing. Cancer Cytopathol. 2011;119(2):102-10. PMID: 21287691.

Zhao M, Dumur CI, Holt SE, Beckman MJ, Elmore LW. Multipotent adipose stromal cells and breast cancer development: Think globally, act locally. Mol Carcinog. 2010; 49(11):923-7. PMID: 20842668; PubMed PMCID: PMC3276248.

Dumur CI, Campbell DJ, DeWitt JL, Oyesanya RA, Sirica AE. Differential gene expression profiling of cultured neu-transformed versus spontaneously-transformed rat cholangiocytes and of corresponding cholangiocarcinomas. Exp Mol Pathol. 2010; 89(3):227-35. PMID: 20816680; PMCID: PMC2981699.

Dumur CI, Ladd AC, Wright HV, Penberthy LT, Wilkinson DS, Powers CN, Garrett CT, DiNardo LJ. Genes involved in radiation therapy response in head and neck cancers. Laryngoscope. 2009; 119(1):91-101. PubMed PMID: 19117295.

Dumur CI, Sana S, Ladd AC, Ferreira-Gonzalez A, Wilkinson DS, Powers CN, Garrett CT. Assessing the impact of tissue devitalization time on genome-wide gene expression analysis in ovarian tumor samples. Diagn Mol Pathol. 2008;17(4):200-6. PMID: 18382347.

Dumur CI, Lyons-Weiler M, Sciulli C, Garrett CT, Schrijver I, Holley TK, Rodriguez-Paris J, Pollack JR, Zehnder JL, Price M, Hagenkord JM, Rigl CT, Buturovic LJ, Anderson GG, Monzon FA. Interlaboratory performance of a microarray-based gene expression test to determine tissue of origin in poorly differentiated and undifferentiated cancers. J Mol Diagn. 2008;10(1):67-77. PMID: 18083688; PMCID: PMC2175545.

Dumur CI, Nasim S, Best AM, Archer KJ, Ladd AC, Mas VR, Wilkinson DS, Garrett CT, Ferreira-Gonzalez A. Evaluation of quality-control criteria for microarray gene expression analysis. Clin Chem. 2004;50(11):1994-2002. PMID: 15364885.

Dumur CI, Garrett CT, Archer KJ, Nasim S, Wilkinson DS, Ferreira-Gonzalez A. Evaluation of a linear amplification method for small samples used on high-density oligonucleotide microarray analysis. Anal Biochem. 2004;331(2):314-21. PMID: 15265737.

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