Virginia Commonwealth University Service 

Professor, Department of Pathology
Director of Pathology Information Systems
Director of Clinical Chemistry
Pathology Quality Management Program, Chair

Education

Postdoctoral Fellow in Clinical Chemistry (1973 - 1975)
Department of Pathology, Division of Clinical Chemistry
Ohio State University, College of Medicine, Columbus, Ohio 43210

PhD Biochemistry (1973)
University of Arizona, Tucson, Arizona 85721

Licenses & Certifications

American Board of Clinical Chemistry

Awards

American Association for Clinical Chemistry, Award for Outstanding Contributions to Clinical Chemistry (2007)

American Association for Clinical Chemistry, Presidential Citation (2007)

Clinical and Laboratory Standards Institute, Award for Excellence in Consensus Management (2007)

American Association for Clinical Chemistry, Capital Section, Miriam Reiner (2006) and Joseph H. Roe (1997) Awards for contributions to the field of clinical chemistry

Editorial Advisory Boards

Clinical Chemistry, Associate Editor

Professional Service

Clinical and Laboratory Standards Institute (CLSI; formerly NCCLS),
Treasurer and Board of Directors

CLSI Sub-committee: Validate and Implement Reference Materials

CLSI Sub-committee: Verification and Comparability of Patient Results in a Healthcare System

CLSI Sub-committee: Laboratory QC Protocols Based on Manufacturer’s Risk Mitigation Information and the Testing Environment

National Institutes of Health, National Kidney Disease Education Program, Laboratory Standardization Working Group, Chair

College of American Pathologists, Chemistry Resource Committee

American Diabetes Association; Insulin Assay Standardization Workgroup

National Glycohemoglobin Standardization Program, Steering Committee

International Organization for Standardization (ISO), Technical Committee 212, Clinical laboratory testing and in vitro diagnostic test systems, representing the American Association for Clinical Chemistry

United States Technical Advisory Group to ISO Technical Committee 212, Executive Committee

International Federation of Clinical Chemistry and Laboratory Medicine (IFCC); Working group for standardization of albumin in urine, Chair

IFCC; Working Group for Standardization of Thyroid Function Tests

IFCC; Working Group for Glomerular Filtration Rate Assessment

Professional Organizations

American Association for Clinical Chemistry
National Academy of Clinical Biochemistry, Fellow

Research Interests

Standardization and harmonization of clinical laboratory results
Metrologic traceability and commutability of reference and control materials
Informatics in laboratory medicine

Recent Presentations

Radiometer America Conference, San Diego, CA, January 2006.  “National Kidney Disease Education Program, Recommendations from the Laboratory Working Group.”

The University of Texas Health Science Center at San Antonio, Audioconference, February 2006.  “Estimating GFR from serum creatinine: recommendations of the NKDEP Laboratory Working Group.”

Bloedgas Symposium, Utrecht, NL, April 2006.  “New creatinine calibration standardization program: eliminate the bias between methods to improve the reliabiilty of estimated Glomerular Filtration Rate.”

American Association for Clinical Chemistry, Expert Access Program, May 2006.  “Reporting Estimated GFR from Serum Creatinine:  Recommendations from the Laboratory Working Group of the National Kidney Disease Education Program.”

American Association for Clinical Chemistry National Meeting, 2000-2007. Workshop on:  Lipid and Lipoprotein Coronary Risk Factors:  What and How to Measure; "New tests for traditional markers".

American Association for Clinical Chemistry National Meeting, Chicago, IL, July 2006. Symposium on Estimating GFR:  Improving early detection of kidney disease;  “Estimating GFR from Serum Creatinine:  Issues and Recommendations for Reporting.”

Abbott Diagnostics, August 2006. Webcast presentation on Chronic Kidney Disease, the Role of the Clinical Laboratory; “Issues and recommendations for reporting estimated GFR from serum creatinine.”

American Association for Clinical Chemistry, October 2006. Audioconference on Improving the Early Detection of Kidney Disease; “Issues and recommendations for reporting estimated GFR from serum creatinine.”

Kidney Disease Improving Global Outcomes, Amsterdam, Netherlands, October 2006, Controversies Conference:  CKD as a Global Public HealthProblem:  Approaches and Initiatives; “Creatinine standardization update.”

American Association for Clinical Chemistry, Capital Section Annual Awards Dinner, December 2006.  “Issues and recommendations for reporting estimated GFR from serum creatinine.”

American Association for Clinical Chemistry, Capital Section Spring Meeting, Richmond, VA, April 2007, “eGFR:  estimating glomerular filtration rate from serum creatinine.”

National Kidney Disease Education Program and International Federation of Clinical Chemistry and Laboratory Medicine Joint Conference on Albumin Standardization, Washington, DC, April 2007; “Information from EQAS programs on performance attributes of routine methods: USA and Australia” and “Status of serum creatinine standardization program.”

American Association for Clinical Chemistry, Connecticut Valley Section Meeting, Meriden, CT, May 2007, “Estimating eGFRfrom serum creatinine.”

American Diabetes Association, Manufactures Forum on Insulin Standardization, San Diego, CA, July 2007; “Insulin standardization phase 3 protocol,” and “Insulin standardization phase 3 results.”

American Association for Clinical Chemistry, Philadelphia Section Meeting, Philadelphia, PA, Dec 2007, “Estimating glomerular filtration rate from serum creatinine.”

Recent Publications

Miller WG. Specimen materials, target values and commutability for external quality assessment (proficiency testing) schemes. Clin Chim Acta 2003;327:25-37.

Miller WG , Myers GL, Ashwood ER, Killeen AA, Wang E, Thienpont LM, Siekmann L. Creatinine Measurement: State of the Art in Accuracy and Inter-Laboratory Harmonization. Arch Pathol Lab Med 2005;129:297-304.

Mullins IM, Siadaty MS, Lyman J, Scully K, Garrett CT, Miller WG , Muller M, Robson B, Apte C, Weiss S, Rigoutsos I, Platt D, Cohen S, Knaus WA. Data Mining and Clinical Data Repositories: Insights from a 667,000 Patient Data Set. J Comp Biol Med 2006;36:1357-77.

Myers GL, Miller WG, Coresh J, Fleming J, Greenberg N, Greene T, Hostetter T, Levey AS, Panteghini M, Welch M, John H Eckfeldt JH. Recommendations for Improving Serum Creatinine Measurement: A Report from the Laboratory Working Group of the National Kidney Disease Education Program. Clin Chem 2006;52:5-18.

Miller WG, Myers GL, Rej R. Why commutability matters. Clin Chem 2006;52:553-4 (editorial).

Miller WG, Myers GL, Eckfeldt JH. Reporting calculated GFR from serum creatinine. www.bloodgas.org (April 2006).

Schumann G, Aoki R, Ferrero CA, Ehlers G, Ferard G, Gella FJ, Jorgensen PJ, Kanno T, Kessner A, Klauke R, Kytzia HJ, Lessinger JM, Miller WG, Nagel R, Pauwels J, Schimmel H, Siekmann L, Weidemann G, Yoshida K, Ceriotti F. IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 degrees C. Clin Chem Lab Med 2006;44:1146-55.

Panteghini M, Myers GL, Miller WG, Greenberg N. The importance of metrological traceability on the validity of creatinine measurement as an index of renal function. Clin Chem Lab Med 2006;44:1187–1192.

Salit ML, Ciesiolka T, Greenberg N, Miller RR, Miller WG, Myers GL, Panteghini M, Schumann G, Siekmann L, Sogin D. Metrological traceability and its implementation; a report. CLSI document X5-R, Clinical and Laboratory Standards Institute, Wayne, PA, 2006.

Miller WG, Gibbs EL, Jay DW, Pratt KW, Rossi B, Vojt CM, Whitehead P. Preparation and testing of reagent water in the clinical laboratory; approved guideline – fourth edition. CLSI document C3-A4, Clinical and Laboratory Standards Institute, Wayne, PA, 2006.

Westgard JO, Miller WG, Allen K, Boone DJ, Caines P, Cooper G, Garber C, Greenberg N, Jain CP, Linnet K, Russek-Cohen E, Vaks JE. Statistical Quality control for quantitative measurement procedures: principles and definitions; approved guideline – third edition. CLSI document C24-A3, Clinical and Laboratory Standards Institute, Wayne, PA, 2006.

Miller WG. Principles of spectrophotometry and related photometric techniques. In Contemporary Practice in Clinical Chemistry, ed. by Clarke W and Dufour DR, AACC Press 2006, p 65-76.

Miller WG. Quality Control. In:  Contemporary Practice in Clinical Chemistry, ed. by Clarke W and Dufour DR, AACC Press 2006, p 143-156.

Miller WG. Quality Control. In:  Henry’s Clinical Diagnosis and Management by Laboratory Methods, 21st Edition, ed. by McPherson RA and Pincus MR, Saunders Elsevier 2007, p 99-111.

Miller G, Myers GL, Eckfeldt JH, Greenberg N. Calculating eGFR using the MDRD equation (letter). Q J Med 2007; advance web access January 10, 2007.

Marcovina S, Bowsher RR, Miller WG, Staten M, Myers G, Caudill SP, Campbell SE, Steffes MW. Standardization of Insulin Immunoassays: Report of the American Diabetes Association Workgroup. Clin Chem 2007;53:711-716.

Thienpont LM, Beastall G, Christofides ND, Faix JD, Ieiri T, Miller WG, Miller R, Nelson JC, Ross HA, Ronin C, Michael Rottmann M, Thijssen JH, Toussaint B. Measurement of free thyroxine in laboratory medicine – proposal of measurand definition. Clin Chem Lab Med 2007;45:563–564.

Miller WG. Controlling Chronic Kidney Disease, Estimating glomerular filtration rate from serum creatinine is explored. Advance for Administrators of the Laboratory 2007;16:54.

Miller WG, Myers GL, Eckfeldt JH. Response to:  Krouwer J. A recommended improvement for specifying and estimating serum creatinine performance. Clin Chem 2007;53:1716-1717 (Letter).

Vesper HW, Miller WG, Myers GL.  Reference Materials and Commutability.  Clin Biochem Rev 2007;28:139-147.

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Updated January 22, 2008