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David C. Williams Jr, MD, PhD
Assistant Professor of Pathology
Department of Pathology
Virginia Commonwealth University
July 2006 - Present
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Professional Organizations | Recent Publications
Licenses & Certifications
Medical Licenses (Current)
Commonwealth of Virginia
American Board of Pathology, Anatomic Pathology
American Board of Pathology, Hematology
Postgraduate Medical Training
Virginia Commonwealth University Health System
Richmond, Virginia 2005 - 2006
Laboratory of Chemical Physics, NIDDK, National Institutes of Health
Bethesda, Maryland 2001 - 2005
Duke University Medical Center
Durham, North Carolina 1998 - 2001
MD, University of Virginia School of Medicine
Charlottesville, Virginia 1990 - 1992 and 1997 - 1998
PhD, Biophysics, University of Virginia Graduate School of Arts and Sciences
Charlottesville, Virginia 1992 - 1997
BS, Chemistry, College of William and Mary
Williamsburg, Virginia 1986 - 1990
American Society of Hematology Junior Faculty Scholar Award, 2008-2011
National Institutes of Health, NIGMS, PRAT Fellowship, 2001-2004
Virginia Commonwealth University and Medical Center Appointments
Assistant Professor, Department of Pathology
Co-Director of the Hematology Laboratory
Co-Director of the Tissue and Data Acquisition and Analysis Core
Director of Molecular Hematology
American Society of Hematology, Member
College of American Pathologists, Member
United States and Canadian Academy of Pathology, Member
American Society of Investigative Pathology, Member
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Rahmani, M., Aust, M.M., Attkisson, E., Williams, D.C., Jr., Ferreira-Gonzalez, A., Grant, S.: Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism. Cancer Res. Dec 12, 2012 (epub).
Walavalkar, N.M., Gordon, N., and Williams, D.C., Jr.: Unique features of the anti-parallel, heterodimeric coiled-coil interaction between methyl-cytosine binding domain 2 (MBD2) homologues and GATA zinc finger domain containing 2A (GATAD2A/p66α). J. Biol. Chem. 288:3419-3427, 2013.
Toor, A.A., Payne, K.K., Chung, H.M., Sabo, R.T., Hazlett, A.F., Kmieciak, M., Sanford, K., Williams, D.C., Clark, W.B., Roberts, C.H., McCarty, J.M., and Mankili, M.H.: Epigenetic induction of adaptive immune response in multiple myeloma: sequential azacitidine and lenalidomide generate cancer testis antigen-specific cellular immunity. Br. J. Haematol. 158:700-711, 2012.
Rahmani, M., Aust. M.M., Attkisson, E., Williams, D.C., Jr., Ferreira-Gonzalez, A., and Grant, S.: Inhibition of Bcl-2 anti-apoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process. Blood 119:6089-6098, 2012
Toor, A.A., Sabo, R.T., Chung, H.M., Roberts, C., Manjili, R.H., Song, S., Williams, D.C. Jr., Edmiston, W., Gatesman, M.L., Edwards, R.W., Ferreira-Gonzalez, A., Clark, W.B., Neale, M.C., McCarty, J.M., and Manjili, M.H.: Favorable Outcomes in Patients with High Donor-Derived T Cell Count after in Vivo T Cell-Depleted Reduced-Intensity Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant 18: 794-804, 2012.
Scarsdale, J.N., Webb, H.D., Ginder, G.D., & Williams, D.C. Jr.: Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target methylated DNA sequence. Nuc Acids Res 39:6741-6752, 2011.
Gnanapragasam, M.N., Scarsdale, J.N., Amaya, M.L., Webb, H.D., Desai, M.A., Walavalkar, N.M., Wang, S.Z., Zu Zhu, S., Ginder, G.D., and Williams, D.C., Jr.: p66a-MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by MBD2-NuRD complex. Proc Natl Acad Sci USA 108: 7487-7492, 2011.
Riley, R.S., Williams D.C. Jr., Ross, M., Zhao, S., Chesney, A., Clark, B.D., Ben-Ezra, J.M.: Bone marrow aspirate and biopsy: a pathologist's perspective. II. interpretation of the bone marrow aspirate and biopsy. J Clin Lab Anal 23:259-307, 2009.
Williams, D.C. Jr., Massey, G.V., Russell, E.C., Riley, R.S., & Ben-Ezra, J: Translocation positive acute myeloid leukemia associated with valproic acid therapy. Pediatr Blood Cancer 50:641-643, 2008.
Hu, K., Williams, D.C. Jr., Komlosh, M.E., Cai, M., & Clore, G.M.: Solution NMR structures of productive and non-productive complexes between the A and B domains of the cytoplasmic subunit of the mannose transporter of the Escherichia coli phosphotransferase system. J Biol Chem 283:11024-11037, 2008.
Basu, P., Lung, T.K., Lemsaddek, W., Sargent, T.G., Williams, D.C. Jr., Basu, M., Redmond, L.C., Lingrel, J.B., Haar, J.L., & Lloyd, J.A.: EKLF and KLF2 have compensatory roles in embryonic b-globin gene expression and primitive erythropoiesis. Blood, 110:3417-3425, 2007.
Suh, J-Y, Cai, M, Williams, D.C. Jr., & Clore, G.M. (2006). Solution structure of a post-transition state analog of the phosphotransfer reaction between A and B cytoplasmic domains of the mannitol transporter II mannitol of the Escherichia coli phosphotransferase system. J Biol Chem 281, 8939-8949.
Williams, D.C. Jr ., Lee, J.Y., Cai, M., Bewley, C.A., & Clore, G.M. (2005). Crystal structures of the HIV-1 inhibitory cyanobacterial protein MVL free and bound to Man 3GlcNAc 2: Structural basis for specificity and high-affinity binding to the core pentasaccharide from N-linked oligomannoside. J Biol Chem 280, 29269-29276.
Williams, D.C. Jr ., Cai, M., Suh, J.Y., Peterkofsky, A., & Clore, G.M. (2005). Solution NMR structure of the 48-kDa IIA Mannose-HPr complex of the Escherichia coli mannose phosphotransferase system. J Biol Chem 280, 20775-20784.
Tang, C., Williams, D.C., Jr., Ghirlando, R., & Clore, G.M. (2005). Solution structure of enzyme IIA Chitobiose from the N,N’-diacetylchitobiose branch of the Escherichia coli phosphotransferase system. J Biol Chem 280, 11770-11780.
Miclet, E., Williams, D.C., Jr., Clore, G.M., Boisbouvier, J., & Bax, A. (2004). Relaxation-optimized NMR spectroscopy of methylene groups in proteins and nucleic acids. J Am Chem Soc 126, 10560-10570.
Williams, D.C. Jr ., Cai, M., & Clore, G.M. (2004). Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42 kDa Oct1·Sox2·Hoxb1-DNA ternary transcription factor complex. J Biol Chem 279, 1449-1457.
Cai *. M., Williams*, D.C. Jr., Wang, G., Peterkofsky, A., & Clore, G.M. (2003). Solution structure of the phosphoryl transfer complex between the signal transduction protein IIA Glucose and the cytoplasmic domain of the glucose transporter IICB Glucose of the Escherichia coli phosphotransferase system. J Biol Chem 278, 25191-25206.
* contributed equally.
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