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Collaborative Efforts - Holt Research Laboratory
Dr. Lynne Elmore, Member of the Division of Cellular and Molecular Pathogenesis and Massey Cancer Center.
Collaboration: To elucidate mechanisms of cellular senescence and telomere dysfunction in breast epithelial cells after DNA damage.
Dr. David A. Gewirtz, member Massey Cancer Center
Collaboration: To determine the effects of adriamycin treatment on breast tumor cells, as it relates to telomerase regulation, p53 function, signal transduction pathways (MAP kinase), and the onset of senescence and/or apoptosis.
Dr. Colleen Jackson-Cook, from Pathology's Cytogenetic Diagnostics Laboratory, member Massey Cancer Center
Collaboration: To develop innovative cytogenetic approaches to measure telomere length and apply that to models of heredity and cancer genetics.
Dr. Lawrence Schwartz, member Massey Cancer Center
Collaboration: To establish human mast cell lines using ectopic expression of viral oncogenes telomerase.
Dr. Alphonse E. Sirica, member Massey Cancer Center, Chair of the Division of Cellular and Molecular Pathogenesis
Collaboration: To establish primary billiary epithelial cultures via exogenous telomerase expression and define the role of telomerase in intrahepatic cholangiocarcinogenesis.
Dr. Jolene Windle, member Massey Cancer Center, Director of Transgenic Mouse Facility
Collaboration: To generate transgenic and knockout mice related to our prostate cancer systems as well as utility in define the mechanisms of organismal aging.
Dr. Richard Winn, University of Georgia, Director of Transgenic Fish Facility
Collaboration: To develop transgenic fish as a vertebrate model for aging and carcinogenesis.
Dr. John P. Wise, Sr., University of Southern Maine, Principal Investigator of the Wise Laboratory of Environmental and Genetic
Toxicology
Collaboration: To generate of cell culture models from human lung and marine mammals in order to study environmental toxicology and progression to carcinogenesis
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