Primary Departmental Program Area: Department of Pathology

Areas of expertise and interests: Breast Cancer Pathogenesis; Epithelial-Stromal Interactions; Stem Cell Biology; Telomerase in Cancer and Aging;  

Education

Postdoctoral training.
IRTA Fellowship - Cancer: Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Sponsor: Curtis C. Harris, M.D., Ph.D
1994-1998

PhD in Pathology
Virginia Commonwealth University, Richmond, VA
Dissertation: Cell Lineage Relationships in the Development of Intrahepatic Cholangiocarcinoma Induced by Furan in the Rat. Major Advisor: Alphonse Sirica, PhD
1988-1993

B.A. in Biology
Vanderbilt University, Nashville, TN, 1981-1984

BIRWCH Scholar, Women’s Health Institute, VCU, 2003-2005       

Recipient of a National Institute of Diabetes and Digestive and Kidney Diseases travel award to attend "The Pancreatic Duct Cell" conference in Baltimore, MD, 1991          

Finalist in the Nineteenth Annual John C. Forbes Honors Colloquium for Predoctoral Basic Science Research, VCU, 1991                                             

Graduated cum laude, Vanderbilt University, Nashville, TN, 1984

International Society for Stem Cell Research (member since 2006)

American Association for Cancer Research (associate member since 1994; full member 2006)

Society for Experimental Biology and Medicine (member 1999-2002)

Expert Services
Scientist Reviewer, NIH/NCI Review Panel for T32 and K99/R00 Career Development Award Mechanisms, Alexandria, VA, 2007

Scientist Reviewer, Pathobiology #3 Review Panel, Department of Defense Breast Cancer Research Program, Washington DC, 2006-2008          

Scientist Reviewer, Multidisciplinary Postdoctoral #4, Department of Defense Breast Cancer Research Program, Reston, VA, 2006                         

Grants and Contracts: Active
TEMIN Career Development Award, National Institutes of Health ($542,000 for 5 years, PI), 2005-2010                 

Grants and Contracts: Pending-Submitted
Department of Defense, Breast Cancer Research Program, Concept Award ($111,000 for 1 yr, PI), November 2008     

Grants and Contracts: Past
Massey Cancer Pilot Project ($30,000 for 1 year, Co-I, P.I.: David Gewirtz), 2005-2006                 

Department of Defense, Breast Cancer Concept Award ($111,741 for 1 year, PI), 2005-2006                 

BIRCH Career Development Award, VCU ($41,600 per year, PI), 2003-2005                 

Department of Defense, Breast Cancer IDEA Award ($441,000 for 3 years, Co-I, P.I.: Shawn Holt), 2004-2006

Department of Defense, Prostate Cancer New Investigator Award (Co-I), ($330,000 for 3 years, P.I.: Shawn Holt), 2002-2005

Department of Defense-Army, Breast Cancer IDEA Award (Collaborator) ($450,000 for 3 years, P.I.: David Gewirtz), 2001-2004

Mount Desert Island Biological Laboratories, New Investigator Award (Co-I; $12,000 for 2 years, P.I.: Shawn Holt), 2002

Department of Defense-Army, Breast Cancer Concept Award (Co-I) ($50,000 for 1 year, P.I.: Shawn Holt), 2001-2002

Aid Grant IN-105, American Cancer Society, VCU ($9,500, PI), 2000-2001                 

Breast Cancer Pilot Project, Massey Cancer Center, Richmond, VA ($30,000, PI), 1999-2000

Department of Pathology Research Award, VCU ($9,000, PI), 1997

Research Advising and Mentoring
Graduate Students:  Currently serving as a primary advisor for one Master’s Candidate (Peter Ma) and on the graduate committees of 9 students (representing 4 departments), 2008                

High School: Theodora Daniels, Katelyn Bowman, Sohini Sircar, Jasmine Jonte, Martha Kahlson, Lillian Asiala, Helen Huang, Suraj Mishra, 2008         

Undergraduate: Melissa Landon, Anne Graves, Sarah Thayer, Byrd Davenport, Matthew Lankowski, Eda Kapinova, Carmen Wong, Mary J. Aiken, Mary Beth Bird,   2007-2008       

Medical Students:    Elizabeth Graves (2nd Place in Medical Student Research Day, May 2005), 2005                

Extramural Presentations

Local              
Mini-Med Program, Science Museum of Virginia, Richmond - October 2008              

Metro-Richmond Student Pugwash Conference, Maggie Walker Governor’s School, Richmond, VA - May 2006                    

West End Henrico Rotary Club, Richmond, VA - November 2005           

Regional
Maine Center for Toxicology and Environmental Health, University of Southern Maine, Portland, ME - December 2008         

Department of Anatomy & Cell Biology, East Carolina University, Greenville, NC - November 2005         

The Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD - April 2002                  

The Laboratory of Human Carcinogenesis, National Institutes of Health - May 1993                   

National
Northeast Society of Toxicology, Annual Meeting, Boston, MA - November 2001          

Professional and Community Services

Service To The Community
Member, River Road Presbyterian Church, Richmond, VA, 1998-present              

Board of Directors, Juvenile Diabetes Research Foundation, Richmond, VA, 2000-2003                 

Judge and Reviewer, Richmond Metro Science Fair, Richmond, VA, 2007-2008                

Ordained Elder, River Road Presbyterian Church, Richmond, VA, 2009

Service To The University
Co-Faculty Coordinator, Aging & Stem Cell Society, 2008-present              

Faculty Representative, Honor Council, 2007-present              

Member, Faculty Senate Research Subcommittee, 2007-present              

Member, Faculty Senate, 2006-present              

Member, Graduate Faculty, 2005-present              

Service To The School of Medicine
Breast Cancer and p53 Interest Groups, Massey Cancer Center, 2001-present             

Member, Molecular Genetic Pathology Fellowship Program, 2004-2006                 

Service To The Department
Member, Graduate Education Program, Department of Pathology, 2004-present             

Chair, Department of Pathology Research in Progress, 2000-present              

Department of Pathology Strategic Planning Committee, 2000-2002                 

Member, Pathology Grand Rounds Speaker Committee, 1999-present              

Papers Published In Peer Reviewed Journals

Gooding, L.R., Elmore, L.W., Tollefson, A.E., Brady, H.A. and Wold, W.S. A 14,700 MW protein from the E3 region of adenovirus inhibits cytolysis by tumor necrosis factor. 1988. Cell 53:341-346.

Sirica, A.E., Elmore, L.W. and Sano, N. 1990. Characterization of rat hyperplastic bile ductular epithelial cells in culture and in vivo. Dig. Dis. and Sci., 36:494-501.

Sirica, A.E., Mathis, G.A., Sano, N. and Elmore, L.W.1990. The isolation, culture and transplantation of intrahepatic biliary epithelial cells and oval cells. Pathobiology 58:44-64.

Elmore, L.W. and Sirica, A.E. 1991. Phenotypic characterization of metaplastic intestinal glands and ductular hepatocytes in cholangiofibrotic lesions rapidly induced in the caudate liver lobe of rats treated with furan. Cancer Res., 51:5752-5759.

Elmore, L.W. and Sirica, A.E. 1992. Sequential appearance of intestinal mucosal cell types in the right and caudate liver lobes of furan-treated rats. Hepatology, 16:1220-1226.

Elmore, L.W. and Sirica, A.E. 1993."Intestinal-type" of adenocarcinoma preferentially induced in right/caudate liver lobes of rats treated with furan. Cancer Res., 53:254-259.

Wang, X.W., Vermeulen, W., Coursen, J.D., Giibson, M., Lupold, S.E., Forrester, K., Xu, G., Elmore, L. W., Yeh, H., Hoeijmakers, J.H.J. and Harris, C.C. 1996. The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. Genes and Development, 10:1219-1232.

Elmore, L.W., Hancock, A.R., Chang S-F, Wang, X.W., Callahan, C.A., Geller, D.A., Will, H. and Harris, C.C. 1997. Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. Proc. Natl. Acad. Sci. U.S.A., 94:14707-14712.

Elmore, L.W. and Holt, S.E. 2000. Telomerase and telomere stability: A new class of tumor suppressor? Molecular Carcinogenesis, 28:1-4.

Akalin, A., Elmore, L.W., Forsythe, H.L., Amaker, B.A., McCollum, E.D., Nelson, P.S., Ware, J.L., and Holt, S.E. 2001. A novel mechanism for chaperone-mediated telomerase regulation during prostate cancer progression. Cancer Research. 61:4791-4796.

Elmore, L.W., Domson, K., Moore, J.R., Kornstein, M. and Burks, R.T. 2001. Expression of c-kit in benign and malignant human endometrium: a possible relationship between estrogen and c-kit. Archives of Pathology and Laboratory Medicine, 125:146-149.

Forsythe,H.L. J.L.Jarvis, J.W.Turner, L.W.Elmore, and S.E.Holt. 2001. Stable association of hsp90 and p23 with human telomerase. J Biol. Chem. 276:15571-574.

Elmore, L.W., Ferreira-Gonzales, A., Garrett, C.T., and Holt, S.E. 2002. Adaptation and Real-Time analysis of a fluorescent-based telomerase activity assay. Diagnostic Molecular Pathology, 11:177-185.

L.W.Elmore, C.W. Rehder, M.Di, P.A.McChesney, C.K.Jackson-Cook, D.A.Gewirtz, and S.E.Holt. 2002. Adriamycin induces telomere length-dependent senescence in breast tumor cells. J. Biol. Chem. 277:35509-35515.

L.W.Elmore, H.L.Forsythe, A.Ferreira-Gonzalez, C.T.Garrett, G.M.Clark, and S.E.Holt. 2002. Real-Time Quantitative Analysis of Telomerase Activity in Breast Tumor Specimens using a Highly Specific and Sensitive Fluorescent-based Assay. Diagnostic Molecular Pathology 11: 177-185.

L.W.Elmore, K.C.Turner, L.S.Gollahon, M.R.Landon, C.K.Jackson-Cook, and S.E.Holt. 2002. Telomerase protects cancer-prone cells from chromosomal instability and spontaneous immortalization. Cancer Biology and Therapy 1:395-401.

Forsythe, H.L., Jensen, K.O., Elmore, L.W., and Holt, S.E.. 2002. Ectopic expression of telomerase in human cells provides a growth advantage, extends proliferative life span, and rescues near senescent cells. International Journal of Oncology. 20:1137-1143.

Harvey, S.A., Jensen, K.O., Elmore, L.W., and Holt, S.E. 2002. Pharmacologic approaches to defining the role of chaperones in aging and cancer progression. Cell Stress and Chaperones, 7:230-234.

McChesney,P.A.,Elmore, L.W., and S.E.Holt. 2002. Aging and oxidative damage: are telomeres the target? Comments on Theoretical Biology 7:295-313.

Elmore, L.W., McChesney,P.A. Lankowski,M. and Holt,S.E. 2003. Identification of high levels of telomerase in marine animals. The Bulletin, Mount Desert Island Biological Laboratory 42:40-42.

Nyuyen, B., Elmore, L.W., and Holt,S.E.. 2003. Telomerase as a target for cancer immunotherapy. Cancer Biol Ther. 2:131-136.

Elmore, L.W., Parton,A., Barnes,D.A., and Holt,S.E. 2004. A novel role for telomerase in fish. The Bulletin, Mount Desert Island Biological Laboratory 43:65-67.

McChesney,P.A., Turner,K.C., Elmore, L.W., Jackson-Cook,C.K. and Holt,S.E. 2004. Telomerase resets the homeostatic telomere length and prevents telomere dysfunction in immortalized human cells. DNA Cell Biol. 23:293-300.

Nguyen,B., Elmore, L.W., and Holt,S.E.. 2004. Telomere Maintenance: at the Crossroads of Mismatch Repair? Cancer Biology and Therapy 3:293-295.

Wise,S.S., Elmore, L.W., Antonucci,P.G., Holt,S.E., Bryant,B.H., and Wise,J.P. 2004.Telomerase-mediated lifespan extension of human bronchial cells does not affect hexavalent chromium-induced cytotoxicity or genotoxicity. Cellular and Molecular Biochemisty 255:103-112.

Elmore, L.W., Di,X., Di,Y-D, Holt,S.E., and Gewirtz,D.A.. 2005. Evasion of chemotherapy-induced senescence in breast cancer cell: implications for treatment response. Clin. Cancer Res, 2005 11(7):2637-43.

Gewirtz, D.A. and Elmore, L.W.  2005. Apoptosis as a predominant tumor cell response to chemotherapy and irradiation: A case of TUNEL vision? Curr. Opinion Invest. Drugs 6(12):1199.

Jones,K.R., Elmore, L.W., Povirk,L., Holt,S.E., and Gewirtz,D.A.. 2005. Reciprocal regulation of senescence and apoptosis in response to radiation in the breast tumor cell. Internatl J Radiation Biol. 81(6):445-458.

McChesney,P.A., Elmore, L.W., and Holt,S.E.. 2005. Vertebrate Marine Species as Model Systems for Studying Telomeres and Telomerase. Zebrafish, 1:349-355.

Compton, S.A., Elmore, L.W., and Holt, S.E. 2006 Reduced functional hsp90 induces a NOS-dependent telomere shortening in human tumor cells. Molecular Cell Biology 26: 1452-1462.

Compton,S.A., Elmore, L.W., K.Haydu, C.K.Jackson-Cook and S.E.Holt. 2006. Induction of NOS-Dependent Telomere Shortening after Functional Inhibition of Hsp90 in Human Tumor Cells. Molecular and Cellular Biology 26:1452-1462.

Elmore, L.W., E.Kapinova, S.Sircar, S.Sircar, and S.E.Holt. 2006. Characterization of Telomerase Function in Cell Lines from Japanese Medaka. The Bulletin, Mount Desert Island Biological Laboratory 44:58-59.

Poynter, K. R., Elmore, L.W., and S.E. Holt. 2006. Telomeres and Telomerase in aging and cancer: lessons learned from experimental model systems. Drug Discovery Today: Disease Models 3: 155-160.

Depcrynski, A.N., Elmore, L.W., P.A.McChesney, M.Lankowski, S.Sircar, S.Sircar, and S.E.Holt, 2007. Functional Conservation of Telomerase: from Marine Animals to Humans. The Bulletin, Mount Dessert Island Biological Laboratories.46:75-76.

Elmore, L.W. and S.E.Holt. 2007. Telomerase inhibition as an adjuvant anti-cancer therapy: it's more than just a waiting game. Expert Opinion on Therapeutic Targets, 11(4): 427-430.

Elmore, L.W., A.N.Depcrynski, S.Sircar, and S.E.Holt. 2007. Evolutionary Conservation of the Telomerase Reverse Transcriptase: From Humans to Fish. The Bulletin: Mount Desert Island Biological Laboratory, 46:75-76.

Sankala, H.M., Hait, N.C., Paugh, S.W., Shida, D., Lepine, S., Elmore, L.W., Dent, P., Milstien, S., and Spiegel, S. 2007. Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Research, 67: 10466-74.

Di,X., R.Bellotti, A.T.Bright, E.Gaskins, J.Roberts, D.A.Gewirtz, S.E.Holt and Elmore, L.W. 2008. Induction of a senescence bystander effect in breast cancer cells: implications for treatment design and response. Cancer Biology and Therapy, 7:1-9. *corresponding author.

Elmore, L.W., M.Norris, A.T.Bright, P.A.McChesney, R.Winn, and S.E.Holt. 2008. Upregulation of Telomerase Function during Tissue Regeneration in Aquatic Animals. Exp. Biol. Med., 233:958-967.

Elmore, L.W., R.Forsythe, M.C.Liu, H.L.Forsythe, S.Nasim, and S.E.Holt. 2008. Association of chaperones and telomerase in prostate tumor samples. Oncology Reports, 20:613-617.

Strub,G.M., A.N.Depcrynski, Elmore, L.W., and S.E.Holt. 2008. Recovery from Stress is a Function of Age and Telomere Length. Cell Stress and Chaperones, 13:475-482.

Gewirtz, D.A., Holt SE., and Elmore, L.W.2008. Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation, Biochem Pharm. 76:947-957. *co-corresponding author

Au, D.W.T., Mok, H.O.L., Elmore, L.W., and Holt, S.E. 2008. Japanese medaka: a new vertebrate model for studying telomere biology. Comp. Biochem & Phys., in press (published online August 2008).

Poynter, K.R., Breed, M.S., Bright, A.T., Elmore, L.W., and Holt, S.E. 2008. Genetic inhibition of telomerase: implications for recovery and chemosensitization. Submitted, Molecular Cancer Therapeutics. (favorable reviews – resubmission Jan 2009).

Zhao, M., Ma, P., Dumur, C., Sachs, P., Francis, M.P., Chen, S., Beckman, M., Holt, S.E., and Elmore, L.W. 2008. Multipotent stromal cells reside in mammary adipose tissue and are chemoattracted to breast cancer cells. Manuscript in Preparation. *corresponding author.

Nguyen,B.N., Elmore, L.W., and S.E.Holt. 2008. Nuclear degradation of human telomerase. Manuscript in Preparation.

Nguyen,B.N., Elmore, L.W., and S.E.Holt. 2008. Dominant-negative hTERT induces cytoplasmic degradation of wild-type telomerase. Manuscript in Preparation.

Diehl,M.C., Expression of heat shock protein Hsp90 and its co-chaperone, p23, in human breast cancer tissue arrays. In preparation.

Diehl,M.C., M.O.Idowu, K.Katherine, T.P.York, S.E.Holt, and Elmore, L.W.. Telomere-associated TRF2 Expression during Breast Cancer Progression. In preparation. *corresponding author.

Depcrynski,A.N., Elmore, L.W., P.A.McChesney, M.Lankowski, S.Sircar, S.Sircar, and S.E.Holt. 2008. Functional Conservation of Telomerase: from Marine Animals to Humans. In preparation.

Poynter, K.R., M.C.Diehl, A.T.Bright, Elmore, L.W. and S.E.Holt. 2008. siRNA targeting of telomerase sensitizes breast tumor cells. In Preparation.

Published Abstracts or Proceedings

Sirica, A.E., Mathis, G.A. and Elmore, L.W. Proc. Amer. Assoc. Cancer Res. 31: 19, 1990.

Elmore, L.W.19th Annual John C. Forbes Honors Colloquium, Virginia Commonwealth University, Richmond, VA, 1991.

Elmore, L.W.Pancreatic Duct Cell Conference, Baltimore, MD, 1991.

Elmore, L.W., Williams, T.W. and Sirica, A.E. FASEB J 5:A1759, 1991.

Sirica, A.E. and Elmore, L.W. FASEB J 5:A707, 1991.

Sirica, A.E., Elmore, L.W., Williams, T.W. and Cole, S.L. Hepatology, 14:103A, 1991.

Elmore, L.W. American Association of Cancer Research, San Francisco, CA, April 1994.

Elmore, L.W. Workshop on Neoplastic Transformation in Cultured Human Cell Systems in Cultures: Mechanisms of Carcinogenesis, Chicago, IL. September 1995.

Elmore, L.W., Hancock, A.R., Chang S-F, Wang, X.W., Callahan, C.A., Geller, D.A., Will, H. and Harris, C.C. American Association for Cancer Research. San Diego, CA, April 1997.

Elmore, L.W., A.Akalin, L.S.Gollahon, G.M.Clark, M.M.Grimes, R.T.Burks, A.Ferreira-Gonzalez, C.T.Garrett and S.E.Holt. Molecular Biology of Breast Cancer Conference. Lillihammer, Norway. March 2000.

Elmore, L.W., Landon, M.R., Akalin, A., Gollahon, L.S., Forsythe, H.L., Turner, K.C., Jackson-Cook, C.K. and Holt, S.E.. Geron symposium #3: Telomeres and telomerase in aging and cancer. San Francisco, CA. June 2000.

Elmore, L.W., Sherman, M.E., Seidman, J.D., Kurman, R.J. and Burks, R.T. p53 expression and mutational analysis of primary peritoneal micropapillary serous carcinoma with comparison to typical primary peritoneal serous carcinoma. USCAP. New Orleans, LA, March 2000.

Elmore, L.W., A.Akalin, L.S.Gollahon, G.M.Clark, M.M.Grimes, R.T.Burks, A.Ferreira-Gonzalez, C.T.Garrett, and S.E.Holt. Molecular Biology of Breast Cancer Conference. Lillihammer, Norway. March 2000.

Elmore, L.W., M.R.Landon, A.Akalin, L.S.Gollahon, H.L.Forsythe, K.C.Turner, C.K.Jackson-Cook, S.E.Holt. Geron symposium #3: Telomeres and telomerase in aging and cancer. San Francisco, CA. June 2000.

Forsythe,H.L., Elmore, L.W., K.O.Jensen, and S.E.Holt. Geron symposium #3: Telomeres and telomerase in aging and cancer. San Francisco, CA. June 2000

Quezado, M.M., Dechsukkum, C., Garret, C.T., Ferreira-Gonzalez, A., Kish, V, Broaddus, W.C., Burks, R.T. and Elmore, L.W. WT-1 expression in ovarian and brain cancer cell lines. USCAP. New Orleans, LA, March 2000.

Quezado, M.M., Elmore, L.W., Dechsukkum, C., Garret, C.T., Ferreira-Gonzalez, A., Kish, V, Broaddus, W.C. and Ghatak, N.R. Overexpression of the Wilms' tumor (WT-1) gene in brain cancer cell lines and tissues. American Association of Neuropathology. Atlanta, GA, June 2000.

Wise, S.S., Elmore, L.W., Antonucci, P.G., Holt S.E., Bryant, B.H. and Wise, J.P.. Northeast Society of Toxicology, Groton, CT. October 2000.

Wise,S.S., Elmore, L.W., P.G.Antonucci, S.E.Holt, B.H.Bryant, and J.P.Wise. American College of Toxicology, San Diego, CA. November 2000.

Elmore, L.W. and S.E.Holt. North East Chapter of the Society of Toxicology. Boston, MA. November 2001.

Forsythe, H.L., Jarvis, J.L., Turner, J.W., Elmore, L.W. and Holt, S.E.. Telomeres and Telomerase, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. March 2001.

Gewirtz, D.A., Elmore, L.W., Di, Y-M, Akalin, A.A., Di, Xu and Holt S.E. AACR Annual Meeting. San

Holt, S.E., Elmore, L.W., Akalin, A., Forsythe, H.L., Jensen, K.O., Harvey, S. and Ware, J.L. New Discoveries in Prostate Cancer Biology and Treatment. AACR. Naples, FL. December 2001.

Jensen, K.O., Akalin, A., Forsythe, H.L., Elmore, L.W. and Holt, S.E. Telomeres and Telomerase, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. March 2001.

Wise, J.P., Wise, S.S., Slotnik, M.J., Elmore, L.W., Holt, S.E. and St.Aubin, D.J. Generation of New Marine Cell Lines and Transgenic Species. Mount Desert Island Biological Laboratory, Salisbury Cove, ME. May 2001.

Wise, S.S., Elmore, L.W., Antonucci, P.G., Holt, S.E., Bryant, B.H. and Wise, J.P. Generation of New Marine Cell Lines and Transgenic Species. Mount Desert Island Biological Laboratory, Salisbury Cove, ME. May 2001.

Elmore, L.W., C.I.Dumur, A.Ferreira-Gonzalez, D.A.Gewirtz, and S.E.Holt. AACR: Oncogenomics, Dublin, Ireland, May 2002.

Elmore,L.W., K.C.Turner, C.W.Rehder, L.S.Gollahon, M.R.Landon, C.K.Jackson-Cook, and S.E.Holt. AACR: The role of telomeres and telomerase in cancer, San Francisco, CA. December 2002.

Gewirtz,D.A. Elmore, L.W., Y-M.Di, A.Akalin, and S.E.Holt. American Association for Cancer Research, San Francisco, CA, April 2002.

Harvey,S.A., A.Akalin, Elmore, L.W., D.A.Gewirtz, and S.E.Holt. American Cancer Society of Virginia Annual Meeting, Blacksburg, VA. April 2002.

Harvey,S.A., Elmore, L.W., and S.E.Holt. AACR: The role of telomeres and telomerase in cancer, San Francisco, CA. December 2002.

Holt,S.E., C.I.Dumur, A.Ferreira-Gonzalez, D.A.Gewirtz, and Elmore, L.W. AACR: Oncogenomics, Dublin, Ireland, May 2002.

Holt,S.E., C.I.Dumur, A.Ferreira-Gonzalez, D.A.Gewirtz, and Elmore, L.W. Department of Defense, Era of Hope, Orlando, FL. September 2002.

Holt,S.E., Elmore, L.W., C.W.Rehder, X.Di, P.A.McChesney, C.Jackson-Cook, and D.A.Gewirtz. Molecular Genetics of Aging, Cold Spring Harbor, NY. October 2002.

Holt,S.E., Elmore, L.W., Y-M.Di, A.Akalin, X.Di, P.A.McChesney, and D.A.Gewirtz. Department of Defense, Era of Hope, Orlando, FL. September 2002.

McChesney,P.A., K.C.Turner, C.Jackson-Cook, Elmore, L.W., and S.E.Holt. AACR: The role of telomeres and telomerase in cancer, San Francisco, CA. December 2002.

McChesney,P.A., Elmore, L.W., and S.E.Holt. American Cancer Society of Virginia Annual Meeting, Blacksburg, VA. April 2002.

Elmore, L.W., X,Di, S.E.Holt, and D.A.Gewirtz. AACR Annual Meeting. April 2003.

Elmore, L.W., C.W.Rehder, X.Di, P.A.McChesney, C.K.Jackson-Cook, D.A.Gewirtz, and S.E. Holt. Telomeres and Telomerase. Cold Spring Harbor Meeting, Cold Spring Harbor, NY. May 2003.

Holt,S.E., S.A.Compton, K.O.Jensen, and Elmore, L.W. CaP CURE. New York, NY. November 2003.

Jones, K.R., Elmore, L.W., S.E.Holt, L.Povirk, and D.Gewirtz. AACR Annual Meeting, April 2003.

Compton, S.A., Elmore, L.W., Holt, S.E. Molecular Chaperones and the Heat Shock Response, Cold Spring Harbor, NY, May 2004.

Compton, S.A., K.O.Jensen, Elmore, L.W., and S.E.Holt. AACR and Japanese Cancer Association: Advances in Cancer Research (Molecular and Cellular Biology, Genomics and Proteomics, Targeted Therapeutics, Novel Clinical Trials, Molecular and Genetic Epidemiology/Prevention), Waikoloa, Hawaii January 2004.

Compton, S.A., K.O.Jensen, Elmore, L.W., and S.E.Holt. AACR: Advances in Cancer Research, Waikoloa, Hawaii. January 2004.

Compton, S.A., Elmore, L.W., and S.E.Holt. Molecular Chaperones and the Heat Shock Response: Cold Spring Harbor Meeting, Cold Spring Harbor, NY. May 2004.

Elmore, L.W., Di, X. Gewirtz, D.A., and Holt, S.E. VCU Women's Health Research Day, April 2004.

Elmore, L.W., C.W.Rehder, X.Di, C.K.Jackson-Cook, D.A.Gewirtz, and S.E. Holt. AACR and Japanese Cancer Association: Advances in Cancer Research (Molecular and Cellular Biology, Genomics and Proteomics, Targeted Therapeutics, Novel Clinical Trials, Molecular and Genetic Epidemiology/Prevention), Waikoloa, Hawaii January 2004.

Elmore, L.W., Di, X. Gewirtz, D.A., and Holt, S.E. BIRCH Annual Meeting, National Institutes of Health, Bethesda, MD, October 2004.

Elmore, L.W., Di, X., Jackson-Cook, C.K., Gewirtz, D.A. and Holt, S.E. Senescence, Apoptosis and Cell Cycle International Conference, Glasgow, Scotland, June 2004.

Elmore, L.W., C.W.Rehder, C.K.Jackson-Cook, X.Di, D.A.Gewirtz, and S.E. Holt. AACR: Advances in Cancer Research, Waikoloa, Hawaii. January 2004.

Elmore, L.W., X.Di, C.K.Jackson-Cook, D.A.Gewirtz, and S.E.Holt.. Beatson International Cancer Conference: Cell Cycle, Senescence, Apoptosis, and Cancer. Glasgow, Scotland. June 2004.

Elmore, L.W., X.Di, D.A.Gewirtz, and S.E.Holt. BIRCH Annual Meeting, National Institutes of Health, Bethesda, MD, October 2004.

Gewirtz, D.A., Elmore, L.W., Di, X. and Holt, S.E. AACR Annual Meeting, April 2004.

Holt,S.E., S.A.Compton, K.O.Jensen, and Elmore, L.W.. Beatson International Cancer Conference: Cell Cycle, Senescence, Apoptosis, and Cancer. Glasgow, Scotland. June 2004.

Jensen, K., Elmore, L.W., Holt, S.E. Molecular Chaperones and the Heat Shock Response, Cold Spring Harbor, NY, May 2004.

Jones, K.R., Elmore, L.W., Holt, S.E., Jackson-Cook, C., Povirk, L.F., and Gewirtz, D.A. 95th Annual American Academy of Cancer Research Conference, Orlando, FL, March 2004.

59-Gewirtz, D.A., D.Xu, C.Dumur, S.E.Holt, and Elmore, L.W. AACR Annual Meeting, April 2005.

Compton, S.A., Elmore, L.W., and S.E.Holt. Telomeres and Telomerase: Cold Spring Harbor Meeting, Cold Spring Harbor, NY. May 2005.

Elmore, L.W., Di, X., Gaskins, E., Gewirtz, D.A, and Holt, S.E. AACR Special Conference, La Jolla, CA, September 2005.

Elmore, L.W., X.Di, C.Dumur, S.E.Holt, and D.A.Gewirtz. Era of Hope: Department of Defense Breast Cancer Research Meeting. Philadelphia, PA. June 2005.

Elmore, L.W., X.Di., E.A.Gaskins, D.A.Gewirtz, and S.E.Holt. AACR Special Conference. La Jolla, CA. September 2005.

Gewirtz, D.A., Xu, D., Dumur, C., Holt, S.E., and Elmore, L.W. AACR Annual Meeting, Orlando, FL, April 2005.

Gewirtz, D.A., Xu, D., Dumur, C., Holt, S.E., and Elmore, L.W. Era of Hope, Department of Defense Cancer Research Program Meeting, Philadelphia, PA, June 2005.

Jensen, K.O., Elmore, L.W., and S.E.Holt. Telomeres and Telomerase: Cold Spring Harbor Meeting, Cold Spring Harbor, NY. May 2005.

Poynter, K., Elmore, L.W., and Holt, S.E. Era of Hope, Department of Defense Cancer Research Program Meeting, Philadelphia, PA June 2005.

Depcrynski, A., Elmore, L.W., and Holt S.E. Defining the regulatory mechanisms underlying the hsp90/telomere association. Massey Cancer Center Research Retreat, June 2006.

Elmore, L.W., Henderson, S., Di, X., Gewirtz, D.A., and Holt, S.E. International Symposium on Human Cancer, Bethesda, MD, April 2006.

Elmore, L.W., Henderson, S., Di, X., Gewirtz, D.A., and Holt, S.E. Telomeres and Genome Stability, Villars-sur-Ollon, Switzerland, September 2006.

Elmore, L.W., Henderson, S., Di, X., Gewirtz, D.A., and Holt, S.E. VCU Institute for Women's Health: 2nd Annual Women's Health Research Day, March 2006.

Elmore, L.W., S.C.Henderson, A.T.Bright, X.Di., D.A.Gewirtz, and S.E.Holt. Telomere and Genome Stability, Villars-su-Ollon, Switzerland, August 2006.

Elmore, L.W., S.C.Henderson, X.Di., D.A.Gewirtz, and S.E.Holt. The Laboratory of Human Carcinogenesis International Symposium, April 2006

Elmore, L.W., S.C.Henderson, X.Di., D.A.Gewirtz, and S.E.Holt. WISDM Research Day, VCU, Richmond, VA, April 2006.

Liu, M.C., Elmore, L.W., and Holt, S.E. Effect of chronic inhibition of hsp90 on breast cancer cell phenotype. Massey Cancer Center Research Retreat, June 2006.

Poynter,K.R., Elmore, L.W., and Holt, S.E. VCU Institute for Women's Health: 2nd Annual Women's Health Research Day, March 2006.

Poynter,K.R., Elmore, L.W., and S.E.Holt. Massey Cancer Center Research Retreat, Richmond, VA, June, 2006.

Poynter,K.R., Elmore, L.W., and S.E.Holt. WISDM Research Day, VCU, Richmond, VA, April 2006.

Xu, D., Elmore, L.W., Walker, T. Shiu, R., and Gewirtz, D.A. AACR Annual Meeting, Washington D.C., April 2006.

Compton,S.A., Elmore, L.W., K.S.Haydu, C.K.Jackson-Cook, and S.E.Holt. DoD Prostate Cancer IMPACT meeting, Atlanta, GA. September 2007.

Depcrynski,A., Elmore, L.W., and S.E.Holt. Telomeres and Telomerase, Cold Spring Harbor meeting, May 2007.

Depcrynski,A., Elmore, L.W., and S.E.Holt. Women in Medicine and Science Retreat, VCU, April 2007.

Francis,M.P., P.C.Sachs, G.L.Bowlin, Elmore, L.W., and S.E.Holt. The Stem Cell Summit, Boston, MA. October 2007.

Holt,S.E., M.Norris, S.Sircar, A.T.Bright, R.Winn, and Elmore, L.W. Telomeres and Telomerase, Cold Spring Harbor meeting, Cold Spring Harbor, NY, May 2007.

Liu,M.C., M.Idowu, K.Kimmelshue, S.E.Holt and Elmore, L.W. Telomeres and Telomerase, Cold Spring Harbor meeting, Cold Spring Harbor, NY, May 2007.

Liu,M.C., M.Idowu, K.Kimmelshue, S.E.Holt and Elmore, L.W. Women in Medicine and Science retreat, VCU, April 2007.

Nguyen,B.N., Elmore, L.W., and S.E.Holt. Telomeres and Telomerase, Cold Spring Harbor meeting, Cold Spring Harbor, NY, May 2007.

Sachs,P.C., M.P.Francis, Elmore, L.W., and S.E.Holt. The Stem Cell Summit, Boston, MA. October 2007.

Elmore, L.W., M.Norris, A.T.Bright, P.A.McChesney, R.Winn, and S.E.Holt. Regenerative Medicine Conference, Hilton Head, NC. March 2008.

Francis,M.P., S.A.Sell, Y.M.Moghaddam, P.C.Sachs, S.E.Holt, Elmore, L.W., and G.L.Bowlin. Regenerative Medicine Conference, Hilton Head, NC. March 2008.

Ma,P., M.Francis, Y.Moghaddam, S.Henderson, M.J.Aiken, S.Holt, G.Bowlin and Elmore, L.W. Signaling Pathways in Cancer and Development, Keystone Symposia, Steamboat Springs, CO. March 2008.

Kimmelshue, K., Diehl,M.C., Idowu, M., Holt, S.E. and Elmore, L.W. USCAP Annual Meeting, Denver, CO. March 2008.

Depcrynski,A.N., Elmore, L.W., and Holt, S.E.. VCU Institute for Women's Health 4th Annual Women's Health Research Day, VCU, Richmond, VA. April 2008.

Francis,M.P., Sachs, P.C., Moghaddam, Y.M., G.L.Bowlin, Elmore, L.W., and S.E.Holt. VCU Institute for Women's Health 4th Annual Women's Health Research Day, VCU, Richmond, VA. April 2008.

Ma,P., M.Francis, Y.Moghaddam, S.Henderson, M.J.Aiken, S.Holt, G.Bowlin and Elmore, L.W. VCU Institute for Women's Health 4th Annual Women's Health Research Day, VCU, Richmond, VA. April 2008.

Diehl,M.C., Idowu, M., Kimmelshue, K., T.P.York, Elmore, L.W. and Holt, S.E. VCU Institute for Women's Health 4th Annual Women's Health Research Day, VCU, Richmond, VA. April 2008.

Elmore, L.W. Department of Defense BCRP Era of Hope, Baltimore, MD. June 2008.

Aiken, M.J., Francis, M.P., Bowlin, G., and Elmore, L.W. National Conference of Undergraduate Research (NCUR), Salisbury University, Salisbury, N.C. April 2008.

Depcrynski, A., Elmore, L.W., and Holt, S.E. Massey Cancer Center Research Retreat. VCU, Richmond, VA. June 2008.

Francis,M.P., Sachs, P.C., Moghaddam, Y.M., Bowlin, G.L., Elmore, L.W., and S.E.Holt.  Massey Cancer Center Research Retreat. VCU, Richmond, VA. June 2008.

Diehl,M.C., Idowu, M., Kimmelshue, K., York, T.P., Elmore, L.W., and Holt, S.E. Massey Cancer Center Research Retreat. VCU, Richmond, VA. June 2008.

Books, Book Chapters and Monographs

Sirica, A.E., Elmore, L.W., Williams, T.W. and Cole, S.L. Differentiation potential of hyperplastic bile ductular epithelial cells in rat models of hepatic injury and cholangiocarcinogenesis. Boca Raton, FL, CRC Press, 1992, pp. 183-208.

Elmore, L.W. and Harris, C.C.Hepatocellular Carcinoma in Metabolic and Molecular Basis of Inherited Diseases, eds. B. Vogelstein and K. Kinzler, chapter 37, 1996.

Elmore, L.W. and Harris, C.C.Hepatocellular Carcinoma in The Genetic Basis of Human Cancer (7th edition), eds. B. Vogelstein and K. Kinzler, chapter 42, 1997.

Elmore, L.W. and Harris, C.C. Hepatocellular Carcinoma in The Genetic Basis of Human Cancer (8th edition), eds. B. Vogelstein and K. Kinzler, chapter 42, 1998.

Elmore, L.W. and Harris, C.C.Hepatocellular Carcinoma in Metabolic and Molecular Basis of Inherited Diseases, eds. B. Vogelstein and K. Kinzler, chapter 59, 2000.

Elmore, L.W. and Holt, S.E.. 2001. Cell Proliferation, Telomerase and Cancer. Advances in Cell Aging and Gerontology: Telomerase, Aging and Disease. Elsevier Science, Inc. pp. 89-102.

Elmore, L.W., Wang, X.W. and Harris, C.C. Hepatocellular Carcinoma in Encyclopedia of the Human Genome (Nature Publishing) 2002.

Elmore, L.W. and Holt, S.E. 2003. Diagnosis and Treatment of Human Disease Using Telomerase as a Novel Target. Cancer Drug Discovery and Development, Humana Press, pp.361-376.

Diehl,M.C., Elmore, L.W., and S.E.Holt. 2008. Telomere Dysfunction and the DNA Damage Response, in "Telomeres and Telomerase in Cancer". Springer, Cancer Drug Discovery and Development series. In press.

Depcrynski, A.N., P.C.Sachs, Elmore, L.W., and S.E.Holt. 2008. Regulation of Telomerase Through Transcriptional and Post-Translational Mechanisms, in "Telomeres and Telomerase in Cancer". Springer, Cancer Drug Discovery and Development series. In press.

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Updated May 1, 2009