Grants & Fellowships

NCI/NIH; The Howard Temin Award, 2005-2010 (P.I)
Department of Defense, Breast Cancer Concept Award, 2005-2006 (P.I)
Department of Defense, Breast Cancer IDEA Award, 2004-2006 (Co-I)
Massey Cancer Center, Richmond, VA, 2005-2006 (Co-I)
Aid Grant IN-105, American Cancer Society, VCU, Richmond, VA, 2000-2001
Breast Cancer Pilot Project, Massey Cancer Center, Richmond, VA, 1999-2000
Department of Pathology Research Award, VCU, Richmond, VA, 1999
BIRCWH Health Institute Scholar, VCU, Richmond, VA, 2002-2005
IRTA Postdoctoral Fellowship, National Cancer Institute, NIH, Bethesda MD, 1993-1997
A.D. Williams Pre-Doctoral Fellowship, VCU, Richmond, VA, 1990-1993

Education

PhD in Pathology
Virginia Commonwealth University, Richmond, VA
Dissertation: Cell Lineage Relationships in the Development of Intrahepatic Cholangiocarcinoma Induced by Furan in the Rat. Major Advisor: Alphonse Sirica, PhD
1988-1993

B.A. in Biology
Vanderbilt University, Nashville, TN, 1981-1984

Professional and Community Services

Member, Pathology Grand Rounds Committee, VCU, 1999-present
Member, Molecular Genetics Pathology Program Committee, VCU, 2003-2006
Member, Advisory Board for Student Women in Medicine, VCU, 2006
Member, VCU Graduate Committee, 2005-present
Member, Pathology Graduate Education Committee, 2004-present
VCU Faculty Senate, 2006-present
Chair, Research in Progress Seminar Series, 2003-present
VCU Faculty Senate Research Subcommittee, 2007-present
VCU Honor Council Faculty Representative, 2007-present
Breast Cancer Research Interest Group, Massey Cancer Center, Richmond, VA, 2007-present
p53 Working Group, Massey Cancer Center, Richmond, VA 2003-present
 Panel Member, Concept and Synergy Award Programs, Department of Defense Breast Cancer Research Program, Washington D.C. 2006-2007
Panel Member, NIH KO-1 Career Development Award Program, National Cancer Institute, Washington D.C. 2007
Mentor, Richmond Metropolitan Science Fair 2004-2007
Judge, Richmond Metropolitan Science Fair 2007
Board of Directors, Juvenile Diabetes Research Foundation, Richmond, VA, 2000-2003

Professional Organizations

International Society for Stem Cell Research (member since 2006)
American Association for Cancer Research (member since 1994)

Research Interests

Molecular Mechanisms of Aging & Cancer

Recent Publications

Books and Chapters

Diehl,M.C., L.W.Elmore, and S.E.Holt. 2008. Telomere Dysfunction and the DNA Damage Response, in “Telomeres and Telomerase in Cancer”. Springer, Cancer Drug Discovery and Development series. In press.

Depcrynski,A.N., P.C.Sachs, L.W.Elmore, and S.E.Holt. 2008. Regulation of Telomerase Through Transcriptional and Post-Translational Mechanisms, in “Telomeres and Telomerase in Cancer”. Springer, Cancer Drug Discovery and Development series. In press.

Peer Reviewed Publications

Elmore, L.W Norris, M., Sircar, S., Bright, A.T., McChesney, P.A., Winn, R., and Holt, S.E. 2008. Upregulation of telomerase function during tissue regeneration in aquatic animals. Submitted PNAS.

X.Di, R. Bellotti, A.T. Bright, E.Gaskins, J. Roberts, D.A.Gewirtz, S.E.Holt and Elmore,L.W.. 2008. Induction of a senescence bystander effect in breast cancer cells: implications for treatment design and response. Submitted Cancer Biology and Therapy.

Elmore,L.W., R.Forsythe, M.C.Liu, H.L.Forsythe, S.Nasim, and S.E.Holt . 2008. Association of chaperones and telomerase in prostate tumor samples. Submitted International Journal of Oncology.

Diehl, M.C., Elmore, L.W., and Holt S,E, Telomere Dysfunction and the DNA damage response. 2008 In press.

Depcrynski, A.N., Sachs P.C., Elmore L.W., and Holt S.E. Regulation of telomerase through transcriptional and post-translational mechanisms.2008 In press.

Elmore,L.W. and S.E.Holt . 2007. Telomerase inhibition as an adjuvant anti-cancer therapy: it’s more than just a waiting game. Expert Opinion on Therapeutic Targets, 11:427-30.

Sankala, H.M., Hait, N.C., Paugh, S.W., Shida, D., Lepine, S., Elmore, L.W., Dent, P., Milstein, S., and Spiegel, S. 2007. Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Research. 67:10466-74.

Depcrynski, A.N., L.W.Elmore, P.A.McChesney, M.Lankowski, S.Sircar, S.Sircar, and S.E.Holt . 2007. Evolutional conservation of the telomerase reverse transcriptase: from humans to fish. The Bulletin, Mount Dessert Island Biological Laboratories. 46:75-76.

Elmore,L.W., E.Kapinovai, S.Sircar, S.Sircar, and S.E.Holt. 2006. Characterization of Telomerase Function in Cell Lines from Japanese Medaka. The Bulletin, MDIBL, 44:58-59.

Poynter, K. R., L.W. Elmore, and S.E. Holt. 2006. Telomeres and Telomerase in aging and cancer: lessons learned from experimental model systems. Drug Discovery Today: Disease Models 3: 155-160.

Compton,S.A., Elmore,L.W., and Holt,S.E.. 2006. Reduced Functional Hsp90 Induces a NOS-Dependent Telomere Shortening in Human Tumor Cells . Molecular Cell Biology, 26(4): 1452-1462.

McChesney,P.A., Elmore,L.W., and Holt,S.E.. 2005. Vertebrate Marine Species as Model Systems for Studying Telomeres and Telomerase. Zebrafish, 1:349-355.

Jones,K.R., Elmore,L.W., Povirk,L., Holt,S.E., and Gewirtz,D.A.. 2005. Reciprocal regulation of senescence and apoptosis in response to radiation in the breast tumor cell. Internatl J Radiation Biol. 81(6):445-458.

Gewirtz, D.A. and Elmore,L.W. 2005. Apoptosis as a predominant tumor cell response to chemotherapy and irradiation: A case of TUNEL vision? Curr. Opinion Invest. Drugs 6(12):1199.

Elmore,L.W., X.Di, C.Dumur, S.E.Holt, and D.A.Gewirtz. 2005. Evasion of chemotherapy-induced senescence: implications for treatment response. Clin Cancer Res. 11:2637-43.

McChesney,P.A., K.C.Turner, L.W.Elmore, C.K.Jackson-Cook, and S.E.Holt. 2004. Telomerase resets the homeostatic telomere length and prevents telomere dysfunction in immortalized human cells. DNA and Cell Biology 23:293-300.

Elmore,L.W., Parton,A., Barnes,D.A., and Holt,S.E. 2004. A novel role for telomerase in fish. The Bulletin, Mount Desert Island Biological Laboratory 43:65-67.

Wise,S.S., L.W.Elmore, P.G.Antonucci, S.E.Holt, B.H.Bryant, J.P.Wise. 2004. Telomerase-mediated lifespan extension of human bronchial cells does not affect hexavalent chromium-induced cytotoxicity or genotoxicity. Molecular and Cellular Biochemistry 255:103-111.

Nguyen,B., L.W.Elmore, and S.E.Holt. 2003. Telomerase as a target for cancer immunotherapy. Cancer Biol and Ther 2:131-136.

Elmore, L.W., McChesney,P.A. Lankowski,M. and Holt,S.E. 2003. Identification of high levels of telomerase in marine animals. The Bulletin, Mount Desert Island Biological Laboratory 42:40-42.

Elmore,L.W. and S.E.Holt. 2003. Diagnosis and Treatment of Human Disease Using Telomerase as a Novel Target. Cancer Drug Discovery and Development, Humana Press, pp. 361-376.

Elmore,L.W., C.W.Rehder, M.Di, P.A.McChesney, C.K.Jackson-Cook, D.A.Gewirtz, and S.E.Holt. 2002. Adriamycin-induced replicative senescence in tumor cells requires functional p53 and telomere dysfunction. J. Biol. Chem. 277:35509-35515.

Elmore,L.W., K.C.Turner, L.S.Gollahon, M.R.Landon, C.K.Jackson-Cook, and S.E.Holt. 2002. Telomerase protects cancer-prone cells from chromosomal instability and spontaneous immortalization. Cancer Bio & Ther 1:395-401.

McChesney,P.A., Elmore, L.W. and Holt, S.E. 2002. Aging and oxidative damage: are telomeres the target? Comments on Theoretical Biology 7:295-313.

Elmore,L.W., H.L.Forsythe, A.Ferreira-Gonzalez, C.T.Garrett, G.M.Clark, and S.E.Holt. 2002. Real-Time Quantitative Analysis of Telomerase Activity in Breast Tumor Specimens using a Highly Specific and Sensitive Fluorescent-based Assay. Diagnostic Molecular Pathology 11:177-185.

Harvey,S.A., K.O.Jensen, L.W.Elmore, and S.E.Holt. 2002. Pharmacological approaches to defining the role of chaperones in aging and prostate cancer progression. Cell Stress and Chaperones 7:230-234.

Forsythe,H.L., K.O.Jensen, L.W.Elmore, and S.E.Holt. 2002. Ectopic expression of telomerase in human cells provides a growth advantage, extends proliferative life span, and rescues near senescent cells. International Journal of Oncology 20:1137-1143.

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Updated January 25, 2008