Molecular Mechanisms of Aging and Cancer Initiation and Progression
Grants & Fellowships
B.A. in Biology 1985-1989
The Colorado College, Colorado Springs, CO
PhD in Genetics 1989-1994
Texas A&M University, College Station, TX
Dissertation: Sequence determinants for DNA binding specificity and transient DNA replication by the BPV-1 E1 protein; Major Professor: Van G. Wilson, PhD
Postdoctoral Training 1994-1998
Postdoctoral Fellow, Department of Cell Biology and Neuroscience
The University of Texas Southwestern Medical Center, Dallas, TX
Sponsors: Jerry W. Shay, PhD and Woodring E. Wright, MD, PhD
The V Foundation Scholars Program, Cary, NC, 2000-2002
Outstanding Presenter, Research Symposium, Texas A&M Health Science Center, College Station, TX 1994
Outstanding Graduate Student Government Member, Texas A&M University, College Station, TX 1994
Professional and Community Service
Xing,J.G., L.E.J.Lee, L.Fan, P.Collodi, S.E.Holt, and N.C.Bols. 2008. Initiation of a Zebrafish Blastula Cell Line on Rainbow Trout Stromal Cells and Subsequent Development under Feeder-Free Conditions into a Cell Line, ZEB2J. Zebrafish 5: 49-63.
Elmore,L.W., R.Forsythe, M.C.Liu, H.L.Forsythe, S.Nasim, and S.E.Holt. 2008. Association of chaperones and telomerase in prostate tumor samples. Oncology Reports 20: 613-617.
Elmore,L.W., M.Norris, A.T.Bright, P.A.McChesney, R.Winn, and S.E.Holt. 2008. Upregulation of Telomerase Function during Tissue Regeneration in Aquatic Animals. Exp. Biol. Med. 233: 958-967
Di,X., R.Bellotti, A.T.Bright, E.Gaskins, J.Roberts, D.A.Gewirtz, S.E.Holt and L.W.Elmore. 2008. Induction of a senescence bystander effect in breast cancer cells: implications for treatment design and response. Cancer Biology and Therapy, 7:1-9.
Strub,G.M., A.N.Depcrynski, L.W.Elmore, and S.E.Holt. 2008. Recovery from Stress is a Function of Age and Telomere Length. Cell Stress and Chaperones, 13:475-82.
Gewirtz,D.A., S.E.Holt, and L.W.Elmore. 2008. Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation. Biochem Pharm, 76:947-57.
Au, D.W.T., H.O.L.Mok, L.W.Elmore, and S.E.Holt. 2008. Japanese medaka: a new vertebrate model for studying telomere biology. Comp. Biochem & Phys., in press.
Poynter, K.R., M.S.Breed, A.T.Bright, L.W.Elmore, and S.E.Holt. 2008. Genetic inhibition of telomerase: implications for recovery and chemosensitization. Submitted, Molecular Cancer Therapeutics, in press.
Elmore,L.W. and S.E.Holt. 2007. Telomerase inhibition as an adjuvant anti-cancer therapy: it’s more than just a waiting game. Expert Opinion on Therapeutic Targets 11:427-430.
Richardson,R.M., B.Nguyen, S.E.Holt, W.C.Broaddus, and H.L.Fillmore. 2007. Ectopic telomerase expression inhibits neuronal differentiation of NT2 neural progenitor cells. Neuroscience Letters, 421:168-72.
Poynter,KP., L.W.Elmore, and S.E.Holt. 2006. Telomeres and telomerase in aging and cancer: lessons learned from experimental model systems. Drug Discovery Today: Disease Models. 3:155-160.
Bryson, S.P., E.M. Joyce, D.J. Martell, L.E.J. Lee, S.E. Holt, K. Fujiki, B. Dixon and N.C. Bols. 2006. Development of a cell line, HEW, from embryos of haddock (Melanogrammus aeglefinius) and defining its capacity to tolerate environmental extremes. Marine Biotechnology 8:641-653.
Compton, S.A., L.W.Elmore, K.Haydu, C.K.Jackson-Cook and S.E.Holt. 2005. Induction of NOS-Dependent Telomere Shortening after Functional Inhibition of Hsp90 in Human Tumor Cells. Molecular and Cellular Biology, in press.
Lai,G.H., Z.Zhang. X.N.Shen, D.J.Ward, J.L.DeWitt, S.E.Holt, R.A.Rozich, D.C.Hixson, and A.E.Sirica. 2005. erbB2/neu transformed rat cholangiocytes recapitulate key cellular and molecular features of human bile duct cancer. Gastroenterology, 129:2047-2057.
JonesK.R., L.W.Elmore, L.Povirk, S.E.Holt, and D.A.Gewirtz. 2005. Reciprocal regulation of senescence and apoptosis in response to radiation in the breast tumor cell. International Journal of Radiation Biology, 81:445-458.
Elmore,L.W., X.Di, Y.M.Di, S.E.Holt, and D.A.Gewirtz. 2005. Evasion of chemotherapy-induced senescence in breast cancer cell: implications for treatment response. Clin. Cancer Res. 11:2637-43.
McChesney,P.A., L.W.Elmore, and S.E.Holt. 2005. Vertebrate Marine Species as Model Systems for Studying Telomeres and Telomerase. Zebrafish, 1:349-355.
Leach,N.T., C.Rehder C, K.Jensen K, S.Holt, and C.Jackson-Cook. 2004. Human chromosomes with shorter telomeres and large heterochromatin regions have a higher frequency of acquired somatic cell aneuploidy. Mech Aging Dev. 125:563-73.
McChesney,P.A., K.C.Turner, L.W.Elmore, C.K.Jackson-Cook, and S.E.Holt. 2004. Telomerase resets the homeostatic telomere length and prevents telomere dysfunction in immortalized human cells. DNA and Cell Biology 23:293-300.
Wise,S.S., L.W.Elmore, P.G.Antonucci, S.E.Holt, B.H.Bryant, J.P.Wise. 2004. Telomerase-mediated lifespan extension of human bronichal cells does not affect hexavalent chromium-induced cytotoxicity or genotoxicity. Molecular and Cellular Biochemistry 255:103-111.
Nguyen,B., L.W.Elmore, and S.E.Holt. 2003. Telomerase as a target for cancer immunotherapy. Cancer Biol & Ther 2:131-136.
Elmore,L.W., C.W.Rehder, M.Di, P.A.McChesney, C.K.Jackson-Cook, D.A.Gewirtz, and S.E.Holt. 2002. Adriamycin-induced replicative senescence in tumor cells requires functional p53 and telomere dysfunction. J. Biol. Chem. 277:35509-35515.
Elmore,L.W. K.C.Turner, L.S.Gollahon, M.R.Landon, C.K.Jackson-Cook, and S.E.Holt. 2002. Telomerase protects cancer-prone cells from chromosomal instability and spontaneous immortalization. Cancer Bio & Ther 1:395-401.
Elmore,L.W., H.L.Forsythe, A.Ferreira-Gonzalez, C.T.Garrett, G.M.Clark, and S.E.Holt. 2002. Real-Time Quantitative Analysis of Telomerase Activity in Breast Tumor Specimens using a Highly Specific and Sensitive Fluroescent-based Assay. Diagnostic Molecular Pathology 11:177-185.
Harvey,S.A., K.O.Jensen, L.W.Elmore, and S.E.Holt. 2002. Pharmacological approaches to defining the role of chaperones in aging and prostate cancer progression. Cell Stress and Chaperones 7:230-234.
Akalin,A., L.W.Elmore H.L.Forsythe, B.A.Amaker, E.D.McCollum, P.S.Nelson, J.L.Ware, and S.E.Holt. 2001. A novel mechanism for chaperone-mediated telomerase regulation during prostate cancer progression. Cancer Research. 61:4791-4796.
Forsythe,H.L. J.L.Jarvis, J.W.Turner, L.W.Elmore, and S.E.Holt. 2001. Stable association of hsp90 and p23 with human telomerase. J Biol. Chem. 276:15571-15574.
Elmore,L.W. and S.E.Holt. 2000. Telomerase and telomere stability: A new class of tumor suppressor? Molecular Carcinogenesis 28:1-4.
Ouellette,M., M.Liao, B.Shea-Herbert, M.Johnson, S.E.Holt, H.S.Liss, J.W.Shay, and W.E.Wright. 2000. Subsenescent Telomere Lengths in Fibroblasts Immortalized by Limiting Amounts of Telomerase. Journal of Biological Chemistry 275:10072-10076.
Savre-Train,I., L.S.Gollahon, and S.E.Holt. 2000. Clonal heterogeneity in telomerase activity and telomere length in tumor-derived cell lines. Proceedings of the Society for Experimental Biology & Medicine 223:379-388.
Tesmer,V.M., L.P.Ford, S.E.Holt, B.C.Frank, X.Yi, D.L.Aisner, M.Ouellette, J.W.Shay, and W.E.Wright. 1999. Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro. Molecular and Cellular Biology 19:6207-6216.
Holt,S.E. and J.W.Shay. 1999. The role of telomerase in cellular proliferation and cancer. Journal of Cellular Physiology 180:10-18.
Holt,S.E., V.M.Tesmer, D.L.Aisner, J.Baur, M.Dy, M.Ouellette, D.O.Toft, J.B.Trager, G.B.Morin, W.E.Wright, J.W.Shay, and M.A.White. 1999. Functional requirement of p23 and hsp90 in telomerase complexes. Genes and Development 13:817-82
Updated February 19, 2010