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cellular and molecular pathogenesis

The study of cellular and molecular mechanisms of disease

Pathogenesis Home | Division Chairman | Postdoctoral Research Positions Available

Curriculum Vitae (Abbreviated)

Guan-Hua Lai, PhD

 

Guan-Hua Lai, PhD
Past Post-Doctoral Trainee/Fellow, Department of Pathology 
Virginia Commonwealth University/Medical College of Virginia Campus

 

 

Position Post-Doctoral Fellow, Department of Pathology
Virginia Commonwealth University/Medical College of Virginia Campus,
Richmond, VA
Education PhD in Molecular Biology, Shanghai Second Medical University, July, 1997 
Bachelor of Medicine, Suzhou Medical College, July, 1986
   
Research Interests Carcinogenesis, prevention and therapy
 
Membership in Professional Organizations
  • American Association for Cancer Research
  • American Society for Investigative Pathology
Recent Publications

Z. Zhang, G-H. Lai, and A.E. Sirica. (2004). Clecoxib-induced apoptosis in rat cholangiocarcioma cells mediated by Akt inactivation and Bax translocation. 39:1028-1037.

Lai, G-H., Zhang, Z., and Sirica, A.E. (2003). Celecoxib acts in a cyclooxygenase-2-independent manner and in synergy with emodin to suppress rat cholangiocarcinoma growth in vitro through a mechanism involving enhanced Akt inactivation and increased activation of caspass-9 and 3. Molecular Cancer Therapeutics, 2:265-271.

Sirica, A.E., Lai, G-H., Endo, K., Zhang, Z. and Yoon, B.: 2002. Cyclooxygenase-2 and ERBB-2 in cholangiocarcinoma: Potential Therapeutic targets. In: Seminars in Liver Disease (G. Fitz, ed.) Invited Paper. 22:303-314.

A.E.Sirica, G-H. Lai and Z. Zhang. (2001). Biliary cancer growth factor pathways, cyclooxygenase-2 and potential therapeutic strategies. J. Gastroenterology and Hepatology, 16: 363-372.

G-H. Lai, S. Radaeva, T. Nakamura, & A.E. Sirica. (2000). Unique epithelial cell production of hepatocyte growth factor/scatter factor by putative precancerous intestinal metaplasias and associated "intestine-type" of biliary cancer chemically induced in rat liver. Hepatology, 31: 1257-65.

G-H Lai, & A.E. Sirica. (1999). Establishment and characterization of a novel rat cholangiocarcinoma culture model. Carcinogenesis, 20: 2335-39.