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RESIDENT
CASE
STUDIES
November 12,
2003: Case 1 Table
of Contents | List
of Diagnoses | Case 1 | Case 2
20 year old male with distal
femur lesion
Discussion by Dan Klink, MD
Chondroblastoma is a tumor of immature
chondroid cells usually in the epiphysis of long bones.
Distribution: 5-25 years old (95% of
cases)
Gross Appearance: Usually comes as
gritty currettings.
Microscopic
Appearance:
- Islands of immature chondroid cells with
a cobblestone architecture
- The cells are usually round with a
central round nucleus
- Other features include giant cells and
calcifications
Diagnostic Criteria
- Immature chondroid cells
- Giant cells
- calcifications (chicken wire type or
more coarse)
- chondroid matrix
- lack of malignant osteoid
Differential Diagnosis:
- Giant cell tumor
- Chondromyxoid fibroma
- Chondroblastic osteosarcoma
- Clear cell chondrosarcoma
References:
- Haber M. et al, Differential diagnosis in surgical pathology, Copyright 2002.
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