Week 1 April 21-25, 2003:
Case 1 Discussion
Table of Contents
| List of Diagnoses | Case 1 | Case 2
| Case 3
with right ovarian mass
adenocarcinoma of the ovary is usually a disease of post-menopausal
women (similar to the other epithelial carcinomas of the ovaries), and it is
rarely bilateral. Like endometrioid ovarian carcinoma, it is often associated with endometriosis.
Different patterns exist – diffuse, tubulocystic, papillary and
trabecular. The most common cell types are clear , hobnail
(prominent bulbous nuclei that protrude into the lumens of tubules
and cysts). The papillae of clear cell carcinomas are often complex
and often contain hyalinized cores. Clear cell adenocarcinoma may contain hyaline bodies. The lumens of the
tubules and cysts
usually contain mucin, confined to the luminal tips of
the cells. Signet ring cells may be present, but very rarely
predominate. Occasionally oxyphilic cells (cells with abundant
eosinophilic cytoplasm) are present.
yolk sac tumor, papillary serous carcinoma, metastatic
renal cell carcinoma
Ordi et al.
reported that while metatstatic renal cell carcinomas, dysgerminomas,
yolk-sac tumors and Sertoli-Leydig cell tumors were often positive
for CD10, all ovarian clear cell carcinomas are negative
Romagosa C, Tavassoli FA, et al. CD10 expression in epithelial
tissues and tumors of the gynecologic tract: A useful marker in the
diagnosis of mesonephric, trophoblastic and clear cell tumors. Am J
Surg Pathol 2003;27(2): 178-186.