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Our funded research enterprise is growing. We have cutting edge programs in: telomerase in aging oncogenesis and proteomics.
We house one of the largest and most sophisticated university-based molecular diagnostics laboratories in the country. Our physicians and scientists are leaders in setting national and international practice standards. Because of this vitality and commitment to the highest standards of excellence, we continue to attract the best and brightest people to our programs.
VCUHS has invested over ten million dollars in our department to support our Functional Genomics Program and Molecular Diagnostics laboratory. Our research programs were strengthened with significant capital equipment acquisitions, including a MALDI mass spectrometer for analysis of proteins, the Affymetrix gene chip instrument, a tissue arrayer, a capillary electrophoresis instrument, and an automated sample preparation instrument.
Our research programs include:
Anatomic Pathology Research
Non-alcoholic Steatohepatitis, NIH, Melissa Contos, MD, VCUHS site Pathologist
- Effects of developmental Stage and of KLF2 on Mouse erythroid Genetic profiles, NIH/NHLBI, Catherine I. Dumur, PhD (Co-investigator)
- Hepatic Oval Cells in Culture and In Vivo, NIH/NCI, Catherine I. Dumur, PhD (Co-investigator)
- Molecular Pathways Leading to Chronic Graft Dysfunction, NIH/NIDDK, Catherine I. Dumur, PhD (Co-investigator)
- Chemoresistance and Motility: Role of Mutant p53 and NF-B2 in Cancer, NIH, Carleton T. Garrett, MD, PhD (Co-investigator)
- Molecular mechanisms underlying recruitment of multipotent stromal cells to the breast tumor microenviroment, DOD, Margaret M. Grimes, MD and Michael O. Idowu, MD, MPH (Co-investigators)
- Lysophosphatidic Acid in Oncogenesis, NIH, Michael O. Idowu, MD, MPH (Co-investigator)
- Phase II Study of 3’Deoxy-3’-18F Fluorothymidine (FLT) in Invasive Breast Cancer, NCI/ACRIN, Michael O. Idowu, MD, MPH (Co-investigator)
Breast Cancer Biology Laboratory
- Genomic Instability and Senescence in Cancer, NIH-NCI, Lynne W. Elmore, PhD (Principle Investigator); Shawn Holt, PhD and David Gewirtz, PhD (Mentors)
- Stromal Cells in Local Fat Depots Contribute to Breast Cancer, DOD, Lynne W. Elmore, PhD (Principle Investigator)
- Molecular Mechanisms underlying Recruitment of Multipotent Adipose Stromal Cells to the Breast Tumor Microenvironment, DOD, Lynne W. Elmore, PhD (Principle Investigator)
Cancer and Metabolic Syndrome Research Laboratory
- IGFBP-3/IGFBP-3R axis in human cancer and the pathophysiology of the IGFBP-related proteins in a variety of human disease, in particular inflammatory disease, diabetes, mellitus, obesity and aging, Youngman Oh, PhD (Principle Investigator)
Cellular and Molecular Pathogenesis Laboratory
- Aging and Genomics, NIH, Colleen K. Jackson-Cook, PhD
Molecular Diagnostics Laboratory