Research Labs

The Department of Pathology at VCUHS has a vibrant and growing research enterprise. Our research and administration space (23,000 nsf) is undergoing a state-of-the-art renovation whose phased completion and move in is expected to occur in 2016/early 2017. Currently, our department has 10 principle investigators involved in basic/translational research. Additionally, most of our faculty in the Anatomic and Clinical Pathology divisions are engaged in wide variety of research projects with clinical impact. As a result, there are numerous opportunities for our residents and fellows to engage our faculty in both short- and long-term research projects.

 

Our research programs include:

 

Anatomic Pathology Research

Bos Lab Research

  • Tumor promoting mechanisms by regulatory T (Treg) cells, Paula D. Bos (Principal Investigator)

Clevenger Lab Research

Elmore Lab Research

  • Genomic Instability and Senescence in Cancer, NIH-NCI, Lynne W. Elmore, PhD (Principal Investigator); Shawn Holt, PhD and David Gewirtz, PhD (Mentors)
  • Stromal Cells in Local Fat Depots Contribute to Breast Cancer, DOD, Lynne W. Elmore, PhD (Principal Investigator)
  • Molecular Mechanisms underlying Recruitment of Multipotent Adipose Stromal Cells to the Breast Tumor Microenvironment, DOD, Lynne W. Elmore, PhD (Principal Investigator)

Harrell Lab Research

  • Identification of genetic mediators of breast cancer liver metastasis, METAvivor, J. Chuck Harrell (Principal Investigator)

Koblinski Lab Research

  •  Studying the role of syndecans in breast cancer metastasis to the brain, Jennifer Koblinski (Principal Investigator)

Oh Lab Research

  • IGFBP-3/IGFBP-3R axis in human cancer and the pathophysiology of the IGFBP-related proteins in a variety of human disease, in particular inflammatory disease, diabetes, mellitus, obesity and aging, Youngman Oh, PhD (Principal Investigator)

Radhakrishnan Lab Research

  • Understanding and targeting protein degradation pathways in cancer, NIH/NCI, Senthil Radhakrishnan (Principal Investigator)

Sirica Lab Research

Jackson-Cook Lab Research

Molecular Diagnostics Laboratory

Clinical Chemistry Laboratory

  • Standardization of urine albumin testing by clinical laboratories, NKDEP/NIDDK, Greg Miller, PhD and Lorin Bachmann, PhD (Principal Investigator)
  • Commutable reference materials for clinical laboratory calibration traceability, Greg Miller, PhD
  • Harmonization assessment of serum albumin methods, Industry Sponsored, Greg Miller, PhD and Lorin Bachmann, PhD (Principal Investigator)
  • Evaluation of analytical performance characteristics of 25-OH Vitamin D methods, Industry Sponsored, Lorin Bachmann, PhD (Principal Investigator)

Transfusion Medicine Research
The faculty members in Transfusion Medicine are engaged in several major research projects.  The “Age of Blood in Children in Pediatric Intensive Care Units  (ABC-PICU)” study is a large, multi-center, randomized, double-blinded control trial aimed at determining if red blood cells stored for seven or fewer days will result in improved clinical outcomes in critically ill children when compared blood issued according to standard practices, which may include blood older than seven days.  In another multi-center study, we are participating in an Investigational New Drug Application (IND) for “Pre-Hospital Use of Plasma for Traumatic Hemorrhage (PUPTH)”.  This study involves the administration of thawed type A plasma in the pre-hospital setting for victims of poly trauma with major hemorrhage with the objectives of demonstrating that thawed plasma can be administered safely in this setting, and that such administration can improve outcomes.  In addition, the apheresis unit contributed data to the NHLBI ReSTART trial, looking at the role of rituximab in the treatment of TTP. The faculty and staff in Transfusion Medicine are also involved in developing new clinical applications for cutting edge technology such as the use of DNA-based testing (genotyping) of red blood cell antigen genes to deduce detailed antigen profiles for patients that present difficult transfusion problems, such as patients who have received multiple or recent transfusions.